[HTML][HTML] Alantolactone inhibits cervical cancer progression by downregulating BMI1

X Sun, H Xu, T Dai, L Xie, Q Zhao, X Hao, Y Sun… - Scientific Reports, 2021 - nature.com
… finger protein that is major component of the polycomb group … Overexpression of BMI1 cells
in humans correlates with the … First, we found that AL could also inhibit BMI-1 expression in …

Carcinogenic roles and therapeutic effects of EZH2 in gynecological cancers

Z Wan, H Jiang, L Li, S Zhu, J Hou, Y Yu - Bioorganic & Medicinal …, 2020 - Elsevier
Polycomb group (PcG) protein is closely related to the tumor … , over-expression of EZH2 and
DNMT1 in ovarian cancer … of EZH2 is elevated in cervical cancer tissue and closely related to …

[HTML][HTML] Critical appraisal of the piRNA-PIWI axis in cancer and cancer stem cells

E Garcia-Borja, F Siegl, R Mateu, O Slaby, A Sedo… - Biomarker …, 2024 - Springer
… factor 4, BMI-1 = polycomb complex protein BMI-1, ALDH1 = … In cervical cancer cells,
PIWIL1 overexpression leads to … PIWIL1 overexpression in endometrial cancer cells promoted …

Multidrug efflux transporter ABCG2: expression and regulation

S Kukal, D Guin, C Rawat, S Bora, MK Mishra… - Cellular and Molecular …, 2021 - Springer
… cellular homeostasis and providing tissue protection against … , hence the name breast cancer
resistance protein (BCRP) [18… to cancer, ABCG2 has been observed to be overexpressed

[HTML][HTML] O-GlcNAcylation: an important post-translational modification and a potential therapeutic target for cancer therapy

Q Lu, X Zhang, T Liang, X Bai - Molecular Medicine, 2022 - Springer
… in breast invasive carcinoma (BRCA) and uterine corpus … multiple cancer types (TCGA tumor)
and adjacent normal tissue … O-GlcNAc and cervical cancer, especially in human papilloma …

[HTML][HTML] EZH2 regulates oncomiR-200c and EMT markers in esophageal squamous cell carcinomas

F Nourmohammadi, MM Forghanifard… - Scientific Reports, 2022 - nature.com
… Since epigenetics regulatory pathways and polycomb proteinsoverexpression and down
regulation of E2F3 and BMI-1 … the promotion of EMT pathway in endometriosis 55 . In gastric …

[HTML][HTML] ALKBH2 inhibition alleviates malignancy in colorectal cancer by regulating BMI1-mediated activation of NF-κB pathway

B Ke, K Ye, S Cheng - World Journal of Surgical Oncology, 2020 - Springer
… site 1 (BMI1) protein is one of the polycomb-group (PcG) family of proteins [14]. Recently, …
important part in tumor development and metastases [15], and BMI-1 overexpression has been …

CBX8 Together with SET Facilitates Ovarian Carcinoma Growth and Metastasis by Suppressing the Transcription of SUSD2

Y Wu, Y Duan, X Li, R Zhao, B Lan, X Zhang… - Molecular Cancer …, 2022 - AACR
Polycomb group proteins are often dysregulated in cancer, … lower than that of cervical cancer
and endometrial carcinoma (8)… , when we overexpressed CBX8 in ovarian carcinoma cells (…

Alteration in the level of NR2F2-AS1/miR-320b/BMI1 differentially converges with the progression of gastric adenocarcinoma toward metastasis

S Ghorbanzadeh, N Pourghasem, R Amiz, M Afsa… - 2023 - researchsquare.com
tissue specimens and matched standard adjacent tissueBMI-1 gene ampli cation and
overexpression in hematological … The polycomb group protein Bmi-1 represses the tumor

[HTML][HTML] Gynecologic cancer, cancer stem cells, and possible targeted therapies

V Keyvani, E Riahi, M Yousefi, SA Esmaeili… - Frontiers in …, 2022 - frontiersin.org
… 87.5% of cervical and uterine cancers and in 58.8% of ovarian … transporter 1 (CTR1) or
overexpression of drug efflux pumps, … Bmi-1 (polycomb complex protein) is an oncogene which …