[HTML][HTML] Functional interaction among lncRNA HOTAIR and microRNAs in cancer and other human diseases

M Cantile, M Di Bonito, M Tracey De Bellis, G Botti - Cancers, 2021 - mdpi.com
… modifiers, such as the Polycomb repressive complex PRC2 [14,15]. … In endometrial carcinoma,
HOTAIR overexpression has a … arrest by directly suppressing Bmi-1 expression, thereby …

Multifaceted behavior of PEST sequence enriched nuclear proteins in cancer biology and role in gene therapy

M Sarfraz, A Afzal, S Khattak… - Journal of Cellular …, 2021 - Wiley Online Library
… The polycomb group protein PRC1 commonly known as Bmi-1Bmi-1 also enhances
telomerase activity in mammary … or overexpression of MAPKAPK3 phosphorylates Bmi-1 and …

Targeting histone onco-modifications using plant-derived products

SP Illam, SP Kandiyil… - Current Drug Targets, 2021 - ingentaconnect.com
… , and overexpression of Mdm2 causes protein ubiquitination in … nents of the Polycomb
group (PcG) complex; proteins form … Bmi-1 and EZH2 protein levels in SCC 13 skin cancer cell …

[HTML][HTML] Therapy resistance, cancer stem cells and ECM in cancer: the matrix reloaded

K Kesh, VK Gupta, B Durden, V Garrido… - Cancers, 2020 - mdpi.com
… the induction of the Polycomb complex protein BMI-1 [28,29]. … integrin α3 is overexpressed
in the cervical cancer cell line SiHa … Additionally, during tissue inflammation, ECM proteins are …

[HTML][HTML] Crucial role of the transcription factors family activator protein 2 in cancer: current clue and views

C Jin, Y Luo, Z Liang, X Li, D Kołat, L Zhao… - Journal of Translational …, 2023 - Springer
… enhancer of zeste 2 polycomb repressive complex 2 subunit (… ), BMI1 proto-oncogene (BMI-1),
POU class 5 homeobox 1 (OCT4… TFAP2A overexpression in ovarian and colorectal cancer

The crosstalk between non-coding RNAs and oxidative stress in cancer progression

Q Sun, X Lei, X Yang - Genes & Diseases, 2024 - Elsevier
… NEAT1, highly expressed in cervical cancer, competitively … Moreover, overexpression of
miR-27a 326 in breast cancer … -139- 351 5p/Bmi-1 pathway, while overproduction promotes …

[HTML][HTML] The role of epigenetic modifications in human cancers and the use of natural compounds as epidrugs: Mechanistic pathways and pharmacodynamic actions

A Bouyahya, H Mechchate, L Oumeslakht, I Zeouk… - Biomolecules, 2022 - mdpi.com
… During uterine development, exposure to gonadal hormones … and the placement of polycomb
repressive complex 2 (PRC2) … found to be overexpressed in cervical cancer and has shown …

[HTML][HTML] An overview of ovarian cancer: the role of cancer stem cells in chemoresistance and a precision medicine approach targeting the Wnt pathway with the …

L Varier, SM Sundaram, N Gamit, S Warrier - Cancers, 2023 - mdpi.com
… associated with endometriosis-associated ovarian cancers are … to be overexpressed in
mucinous epithelial cancer and … expression in primary ovarian cancer tissue and lymph node …

Sustained inactivation of the Polycomb PRC1 complex induces DNA repair defects and genomic instability in epigenetic tumors

CC Rawal, V Loubiere, NL Butova, J Garcia, V Parreno… - 2024 - researchsquare.com
… widespread genomic instability in the cancer tissue. A broad mis-… Mel-18 acts as a tumor
suppressor by repressing Bmi-1 … Mutator phenotypes conferred by MLH1 overexpression and by …

[HTML][HTML] Deregulated microRNAs involved in prostate cancer aggressiveness and treatment resistance mechanisms

H Gujrati, S Ha, BD Wang - Cancers, 2023 - mdpi.com
… -3p is overexpressed in PCa cell lines and patient samples. It … associated with the tumor grade
in uterine cancer [98] and … Several studies have shown that the SRSF1 protein binds to the …