Immunohistochemical analysis of the glial fibrillary acidic protein expression in the experimental acute hepatic encephalopathy

TV Shulyatnikova, VO Tumanskiy - 2021 - dspace.zsmu.edu.ua
… focused on the ammonia neurotoxicity associated with … linked to the mechanism where
ammonia interfering with the cellular … by aggravation of oxidative and nitrosative stress in the brain …

Impacts of ammonia stress on different Pacific whiteleg shrimp Litopenaeus vannamei families and the underlying adaptive mechanisms

D Tong, Z Zhu, J Wu, F Li, J Shen, J Cao, Y Tang… - Aquatic Toxicology, 2023 - Elsevier
… that ammonia exposure can provoke oxidative stress in shrimps (de Lourdes Cobo et al.,
2014; Liang et al., 2016). As a target for oxidative stress, ammonia-induced oxidative stress

Lactoferrin averts neurological and behavioral impairments of thioacetamide-induced hepatic encephalopathy in rats via modulating HGMB1/TLR-4/MyD88/Nrf2 …

RM Essam, MA Saadawy, M Gamal, RM Abdelsalam… - …, 2023 - Elsevier
ammonia, together with lowering brain ammonia and enhancing motor coordination as well
as cognitive performance. Restoration of brain oxidative … neuroinflammation, oxidative stress, …

[HTML][HTML] Hepatocellular Metabolic Abnormalities Induced by Long-Term Exposure to Novel Brominated Flame Retardant, Hexabromobenzene

B Shin, SH Hong, S Seo, CH Jeong, J Kim, E Bae… - Toxics, 2023 - mdpi.com
… excess nitrogen mainly generated by ammonia within the liver [37]. Accumulation of ammonia
induces oxidative/nitrosative stress in astrocytes and is known to cause neurotoxicity [38]. …

[PDF][PDF] Hepatic encephalopathy and treatment modalities: a review article

K Sharma, S Akre, S Chakole, MB Wanjari - Cureus, 2022 - cureus.com
… The neurotoxic ammonia is the most well studied in relation to HE. The gut produces ammonia
as a … As a result, the concentration of ammonia in the systemic circulation is regulated by a …

The tryptophan metabolism, kynurenine pathway and oxidative stress–implications for glioma pathobiology

M Obara-Michlewska - Neurochemistry International, 2022 - Elsevier
… QUIN is an agonist of NMDA receptor and exerts its excitotoxic effects via induction of
oxidative/nitrosative stress, as described above. QUIN was shown to induce ROS in rat brain …

[HTML][HTML] Microglia and astroglia—the potential role in neuroinflammation induced by pre-and neonatal exposure to lead (Pb)

M Gąssowska-Dobrowolska, M Chlubek… - International Journal of …, 2023 - mdpi.com
… microglia, we observed a wide range of neurotoxic effects of Pb on the brain (Figure … ammonia
is toxic to cerebral cells through various mechanisms, including oxidative/nitrosative stress

Acute Liver Failure in Rats Induced Vasogenic Edema and Nitric Oxide Synthase-Nitric Oxide-cGMP Pathway after Differential Regulation of NMDA Receptors in …

S SINGH, A Mukherjee, D Jeswani - 2022 - researchsquare.com
… damage such as matrix metalloproteinase, oxidative and nitrosative stress contribute indirectly
in the … Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal. Biochemical …

Therapeutic Effect of Levetiracetam Against Thioacetamide-Induced Hepatic Encephalopathy Through Inhibition of Oxidative Stress and Downregulation of NF-κB …

K Amirshahrokhi, M Imani - Inflammation, 2024 - Springer
… High levels of ammonia in the brain of patients with HE can activate oxidative stress … It
has been believed that oxidative and nitrosative stress, pro-inflammatory cytokines and NF…

[PDF][PDF] Astrocytic urea cycle detoxifies Aβ-derived ammonia while impairing memory in Alzheimer's disease

YH Ju, M Bhalla, SJ Hyeon, JE Oh, S Yoo, U Chae… - Cell Metabolism, 2022 - cell.com
… toxin clearance and neuroprotection have been contradicting its neurotoxic effects such as
increased oxidative and nitrosative stress, aberrant GABA, and neurodegeneration (Chun et …