Chemical insights into oxidative and nitrative modifications of DNA

CMC Andrés, JMP Lastra, CA Juan, FJ Plou… - International Journal of …, 2023 - mdpi.com
… ’s pairing of nitrogenous bases involves guanine binding to … by free radicals (FR) is the
transformation of guanine into 8-… OH or the carbonate radical [58,59]. In this first step, a cation …

On the irrelevancy of hydroxyl radical to DNA damage from oxidative stress and implications for epigenetics

AM Fleming, CJ Burrows - Chemical Society Reviews, 2020 - pubs.rsc.org
Carbonate radical anion is a potent one-electron oxidant … reactive oxygen and nitrogen
species including superoxide, … the guanine base is oxidized to G + when the Fenton reaction is …

The role of carbonate in catalytic oxidations

SG Patra, A Mizrahi, D Meyerstein - Accounts of Chemical …, 2020 - ACS Publications
… out that carbonates are key participants in a variety of oxidation processes. This was first
attributed to the formation of carbonate anion radicals via the reaction … of carbonates in oxidation

Contribution of oxidation reactions to photo‐induced damage to cellular DNA

J Cadet, D Angelov, P Di Mascio… - Photochemistry and …, 2024 - Wiley Online Library
… a delayed generation of reactive oxygen and nitrogen species giving … such as carbonate
radical anions, sulfate radical anion, … neutral radicals Gua(- H)• of guanine radical cations similar …

The two faces of the guanyl radical: Molecular context and behavior

C Chatgilialoglu - Molecules, 2021 - mdpi.com
radical G(-H) • , also named the guanine radical or neutral … • , ie, the ability of the radical to
be either oxidized or reduced, … to its readily observable nitrogen hyperfine coupling by electron …

Computational Investigation into the Oxidation of Guanine to Form Imidazolone (Iz) and Related Degradation Products

SP Hebert, HB Schlegel - Chemical Research in Toxicology, 2020 - ACS Publications
guanine radical formed by hydroxyl radical addition to C8 of … (16) Their experiments in
this study found significant Iz … , carbonate radical oxidation, or Cu(II) Fenton oxidation of …

Products of oxidative guanine damage form base pairs with guanine

K Kino, T Kawada, M Hirao-Suzuki… - International journal of …, 2020 - mdpi.com
… -2′-deoxyguanosine (cG) is the smallest tandem lesion generated by hydroxyl radical [83]. …
: We have collected information on typical generations of oligomer containing the damage, …

On the relevance of hydroxyl radical to purine DNA damage

C Chatgilialoglu, C Ferreri, MG Krokidis… - Free radical …, 2021 - Taylor & Francis
… A summary of reactive oxygen/nitrogen species (ROS and … species such as H 2 O 2 , singlet
oxygen, carbonate radical anion (CO 3 … Guanine is the most readily oxidized site in DNA and …

One-electron oxidation of guanine derivatives: Detection of 2, 5-diaminoimidazolone and novel guanine-guanine cross-links as major end products

Y Razskazovskiy, EB Campbell, ZD Cutright… - Radiation Physics and …, 2022 - Elsevier
… neutral guanine radicals generated in reactions of guanosine … These include the carbonate
radical anion CO 3 •- (E o (CO … the exocyclic nitrogen of one of the guanine moieties and the …

[图书][B] Computational Investigations into Organic and Bioorganic Reaction Pathways

SP Hebert - 2020 - search.proquest.com
… , while carbonate-guanine radical or carbonate-guanine radicalCarbonate radical-guanine
radical combination was the … of the guanine oxidation products, including oxygen or nitrogen