Characterization of metabolic patterns in mouse oocytes during meiotic maturation

L Li, S Zhu, W Shu, Y Guo, Y Guan, J Zeng, H Wang… - Molecular cell, 2020 - cell.com
… profile of mouse oocytes during in vivo maturation by isolating … to metabolic pathways such
as glutathione/carbon/pyruvate … during meiotic maturation (ie, oxidative phosphorylation and …

Metabolic control of oocyte development

S Zhu, Q Wang - Biology of Reproduction, 2022 - academic.oup.com
mouse oocytes during in vivo maturation, depicting the global metabolic patterns in oocytes.
… The meiotic defects in mouse oocyte with pyruvate dehydrogenase E1 subunit alpha 1 (also …

Reprogramming of glucose metabolism of cumulus cells and oocytes and its therapeutic significance

S Imanaka, H Shigetomi, H Kobayashi - Reproductive Sciences, 2022 - Springer
… Both aerobic glycolysis and oxidative phosphorylation (OXPHOS) … , pyruvate and lactate
are required as an energy source for 2-cell mouse embryos to develop into blastocysts in vitro […

Characterization of carbohydrate metabolism in in vivo-and in vitro-grown and matured mouse antral follicles

AC Herta, L von Mengden, N Akin… - Biology of …, 2022 - academic.oup.com
… boost of pyruvate and lactate uptake in cumulus cells in vivo, … activities, while in vitro, the
metabolic upregulation in all the … [57–59], the oocyte still relies on oxidative phosphorylation (…

Redox Regulation and Oxidative Stress in Mammalian Oocytes and Embryos Developed In Vivo and In Vitro

MLM Hardy, ML Day, MB Morris - International Journal of Environmental …, 2021 - mdpi.com
metabolism and away from oxidative phosphorylation [50]. … over 5 days in the mouse in
vivo. The maternal reproductive … a switch in energy source from pyruvate to glucose [97,98]. In …

α‐Ketoglutarate Improves Meiotic Maturation of Porcine Oocytes and Promotes the Development of PA Embryos, Potentially by Reducing Oxidative Stress through the …

Q Chen, L Gao, J Li, Y Yuan, R Wang… - Oxidative Medicine …, 2022 - Wiley Online Library
… in vitro maturation (IVM) on the maturation of porcine oocytes … D-glucose, 0.91 mm sodium
pyruvate, 0.57 mm cysteine, 75 μg/… to the oxidative phosphorylation of oocytes. Therefore, we …

Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence

D Richani, KR Dunning, JG Thompson… - Human reproduction …, 2021 - academic.oup.com
… formation and supply of pyruvate to the oocyte for ATP production. … oocyte lipid metabolism
for oocyte oxidative phosphorylation … that involves the maturation of oocytes in vitro prior to …

Energy metabolism of the equine cumulus oocyte complex during in vitro maturation

N Lewis, K Hinrichs, HJ Leese, C McG. Argo… - Scientific Reports, 2020 - nature.com
pyruvate results in the highest maturation rates for mouse … We also examined the metabolic
effect of including pyruvate to … of glycolytic and oxidative metabolism in equine oocytes during …

Effects of glucose metabolism pathways on nuclear and cytoplasmic maturation of pig oocytes

J Wen, GL Wang, HJ Yuan, J Zhang, HL Xie, S Gong… - Scientific Reports, 2020 - nature.com
… , pyruvate and lactate was compared between pig and mouse … in CCs is essential for oocyte
cytoplasmic maturation and that … used for in vitro maturation of mouse oocytes were exactly …

Abnormal early folliculogenesis due to impeded pyruvate metabolism in mouse oocytes

K Tanaka, Y Hayashi, A Takehara… - Biology of …, 2021 - academic.oup.com
… [15], suggesting enhanced oxidative phosphorylation (OXPHOS) in developing oocytes. In …
pyruvate metabolism in folliculogenesis up to the secondary follicle in culture as well as in vivo