[HTML][HTML] New perspectives on the therapeutic potential of quercetin in non-communicable diseases: Targeting Nrf2 to counteract oxidative stress and inflammation

L Zhang, LY Xu, F Tang, D Liu, XL Zhao… - Journal of …, 2024 - Elsevier
… In conclusion, Nrf2 activation plays a crucial role in protecting muscles from inflammation-induced
damage and oxidative stress. Nrf2 regulates mitochondrial function, cellular redox …

Nrf2 and oxidative stress: A general overview of mechanisms and implications in human disease

V Ngo, ML Duennwald - Antioxidants, 2022 - mdpi.com
… studied in the disease contexts. This review aims to provide the reader with a general overview
of oxidative stress and Nrf2, including basic mechanisms of Nrf2 activation and regulation…

Targeting oxidative stress in disease: promise and limitations of antioxidant therapy

HJ Forman, H Zhang - Nature Reviews Drug Discovery, 2021 - nature.com
… evaluated as antioxidants have exhibited therapeutic potential in preclinical studies, …
oxidative stress, redox signalling and disease, the mechanisms through which oxidative stress can …

Advances and challenges in therapeutic targeting of NRF2

AT Dinkova-Kostova, IM Copple - Trends in pharmacological sciences, 2023 - cell.com
Activation of the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is
emerging as an attractive therapeutic approach to counteract oxidative stress, inflammation, and …

Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy

S Bono, M Feligioni, M Corbo - Molecular Neurodegeneration, 2021 - Springer
… Although oxidative damage in biological systems has in the past been completely attributed
to ROS, it is becoming increasingly clear that also reactive nitrogen species (RNS) and …

A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases

S Saha, B Buttari, E Profumo, P Tucci… - Frontiers in cellular …, 2022 - frontiersin.org
… So far, we discussed different aspects of Nrf2 signaling pathway in oxidative stress and
inflammation in neurodegenerative diseases, therefore, it is also worthwhile to discuss …

The therapeutic potential of Nrf2 inducers in chronic pain: Evidence from preclinical studies

YQ Zhou, W Mei, XB Tian, YK Tian, DQ Liu… - … & therapeutics, 2021 - Elsevier
… Considering the complexity of oxidative stress, interventions such as administration of Nrf2
inducers might be too simplistic. A better understanding of redox biology under chronic pain …

Bioactive compounds in oxidative stress-mediated diseases: targeting the NRF2/ARE signaling pathway and epigenetic regulation

M Thiruvengadam, B Venkidasamy, U Subramanian… - Antioxidants, 2021 - mdpi.com
… as a promising target against oxidative stress-mediated diseases like diabetes, fibrosis, …
on the NRF2/ARE signaling pathway and its role in oxidative stress-mediated diseases. …

[HTML][HTML] Regulation of immunomodulatory networks by Nrf2-activation in immune cells: Redox control and therapeutic potential in inflammatory diseases

T Pant, N Uche, M Juric, J Zielonka, X Bai - Redox Biology, 2024 - Elsevier
… the burden of these diseases, nuclear factor erythroid 2-related factor 2 (Nrf2) has emerged
… in cellular defense against metabolic and oxidative stress, Nrf2's role in modulating the …

Current evidence to support the therapeutic potential of flavonoids in oxidative stress-related dermatoses

D Xian, M Guo, J Xu, Y Yang, Y Zhao, J Zhong - Redox report, 2021 - Taylor & Francis
… only greatly benefiting people health and dietary ingredients, but also lowering the risk of
health problems, like age-related degenerative diseases, cardiovascular disease, OS-related …