… and diabetes, and it is characterized by impaired cardiac energetics, diastolic dysfunction,
and finally heart … These structural and functional effects were associated with protection of …

… to numerous diseases such as diabetes, hepatic diseases, NDs… that SIRT3 expression through
PGC-1 protects against DA … which mediate activating and others inhibitory phosphorylation…

… cardiac fibrosis [33]. To examine whether NMN treatment could prevent fibrosis via the PDGF
axis, … cardiomyopathy and inhibition of PARP-1 in diabetic mice can protect cardiomyocytes …

… Our study found that the inhibition of PARP-1 activation using PJ34 alleviated Cd-induced …
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis. Exp. …

… , such as diabetic peripheral … activation of the NAD-SIRT1-PGC-1α axis, impairs mitophagy,
and results in the accumulation of damaged mitochondria. NAD supplementation or inhibition …

… heart and energy metabolism, we first discussed the cardiac … It has been reported that
AMPK/SIRT1/PGC-1α pathway was … In addition, activation of the AMPK pathway inhibited CD 36 …

… of PARP-1 that result in a decreased activation of SIRT1. The … –PGC-1–SIRT3 signaling axis
was involved in NAC beneficial … ameliorates CIN by activation of the SIRT1–PGC-1α and its …

… 1α by SIRT1 activates the NAD + -SIRT1-PGC-1α axis, which … mice Protects against hepatic
steatosis through regulation of … and myricetin may inhibit inflammation by activating SIRT1 to …

… Interestingly, PARP-1 inhibition improved mitochondrial … In other pathological conditions,
such as diabetic … For example, Sirt1 deacetylates PGC-1α and activates the Sirt1/PGC-1α axis …

… PARP-1 activation at modest levels is important for DNA … a miR-29b inhibitor upregulated
the expression of SIRT1/PGC-1α. … dysfunction through the downregulation of SIRT1/PGC-1α …