Relevance of mitochondrial dysfunction in heart disease associated with insulin resistance conditions
N de Las Heras, V Lahera - Pflügers Archiv-European Journal of …, 2022 - Springer
… and diabetes, and it is characterized by impaired cardiac energetics, diastolic dysfunction,
and finally heart … These structural and functional effects were associated with protection of …
and finally heart … These structural and functional effects were associated with protection of …
Sirtuin dysregulation in Parkinson's disease: Implications of acetylation and deacetylation processes
… to numerous diseases such as diabetes, hepatic diseases, NDs… that SIRT3 expression through
PGC-1 protects against DA … which mediate activating and others inhibitory phosphorylation…
PGC-1 protects against DA … which mediate activating and others inhibitory phosphorylation…
Nicotinamide mononucleotide attenuates isoproterenol-induced cardiac fibrosis by regulating oxidative stress and Smad3 acetylation
K Wu, B Li, Q Lin, W Xu, W Zuo, J Li, N Liu, T Tu… - Life sciences, 2021 - Elsevier
… cardiac fibrosis [33]. To examine whether NMN treatment could prevent fibrosis via the PDGF
axis, … cardiomyopathy and inhibition of PARP-1 in diabetic mice can protect cardiomyocytes …
axis, … cardiomyopathy and inhibition of PARP-1 in diabetic mice can protect cardiomyocytes …
Luteolin Alleviates Cadmium-Induced Kidney Injury by Inhibiting Oxidative DNA Damage and Repairing Autophagic Flux Blockade in Chickens
K Zhang, J Li, W Dong, Q Huang, X Wang, K Deng… - Antioxidants, 2024 - mdpi.com
… Our study found that the inhibition of PARP-1 activation using PJ34 alleviated Cd-induced …
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis. Exp. …
PARP-1 inhibition protects the diabetic heart through activation of SIRT1-PGC-1α axis. Exp. …
Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases
F Li, C Wu, G Wang - Neuroscience Bulletin, 2024 - Springer
… , such as diabetic peripheral … activation of the NAD-SIRT1-PGC-1α axis, impairs mitophagy,
and results in the accumulation of damaged mitochondria. NAD supplementation or inhibition …
and results in the accumulation of damaged mitochondria. NAD supplementation or inhibition …
[HTML][HTML] Energy metabolism: A critical target of cardiovascular injury
Q Li, S Zhang, G Yang, X Wang, F Liu, Y Li… - Biomedicine & …, 2023 - Elsevier
… heart and energy metabolism, we first discussed the cardiac … It has been reported that
AMPK/SIRT1/PGC-1α pathway was … In addition, activation of the AMPK pathway inhibited CD 36 …
AMPK/SIRT1/PGC-1α pathway was … In addition, activation of the AMPK pathway inhibited CD 36 …
Molecular pathophysiology of acute kidney injury: The role of sirtuins and their interactions with other macromolecular players
Y Rahbar Saadat… - Journal of cellular …, 2021 - Wiley Online Library
… of PARP-1 that result in a decreased activation of SIRT1. The … –PGC-1–SIRT3 signaling axis
was involved in NAC beneficial … ameliorates CIN by activation of the SIRT1–PGC-1α and its …
was involved in NAC beneficial … ameliorates CIN by activation of the SIRT1–PGC-1α and its …
[HTML][HTML] The role of Sirtuin 1 and its activators in age-related lung disease
C Sun, S Bai, Y Liang, D Liu, J Liao, Y Chen… - Biomedicine & …, 2023 - Elsevier
… 1α by SIRT1 activates the NAD + -SIRT1-PGC-1α axis, which … mice Protects against hepatic
steatosis through regulation of … and myricetin may inhibit inflammation by activating SIRT1 to …
steatosis through regulation of … and myricetin may inhibit inflammation by activating SIRT1 to …
Maintenance of NAD+ homeostasis in skeletal muscle during aging and exercise
… Interestingly, PARP-1 inhibition improved mitochondrial … In other pathological conditions,
such as diabetic … For example, Sirt1 deacetylates PGC-1α and activates the Sirt1/PGC-1α axis …
such as diabetic … For example, Sirt1 deacetylates PGC-1α and activates the Sirt1/PGC-1α axis …
The role of hypoxia-associated miRNAs in acquired sensorineural hearing loss
S Safabakhsh, P Wijesinghe, M Nunez… - Frontiers in cellular …, 2022 - frontiersin.org
… PARP-1 activation at modest levels is important for DNA … a miR-29b inhibitor upregulated
the expression of SIRT1/PGC-1α. … dysfunction through the downregulation of SIRT1/PGC-1α …
the expression of SIRT1/PGC-1α. … dysfunction through the downregulation of SIRT1/PGC-1α …