Endurance exercise training suppresses Parkinson disease-induced overexpression of apoptotic mediators in the heart

MD Al-Jarrah, NS Erekat - NeuroRehabilitation, 2021 - content.iospress.com
attenuation in the upregualtion of the apoptotic mediators p53 and active caspase-3 in cardiac
muscles of mice with MPTP-induced chronic Parkinson’s … suppressed the upregulation of …

… some nutraceuticals against manganese-induced Parkinson's disease in rats: possible modulatory effects on TLR4/NLRP3/NF-κB, GSK-3β, Nrf2/HO-1, and apoptotic …

K Abu-Elfotuh, AME Hamdan, AA Mohammed… - Pharmaceuticals, 2022 - mdpi.com
… for attenuation of PD, … mediators including TNF-α, IL-1β, COX2, and iNOS, compared to
normal control rats. This ongoing neuroinflammation may be linked to the depicted upregulation

MicroRNA-181a–2–3p shuttled by mesenchymal stem cell-secreted extracellular vesicles inhibits oxidative stress in Parkinson's disease by inhibiting EGR1 and …

J Ma, X Shi, M Li, S Chen, Q Gu, J Zheng, D Li… - Cell Death …, 2022 - nature.com
… cells (MSCs) might mediate oxidative stress (OS) in Parkinson’s … cell viability and inhibit
apoptosis to suppress the development … that upregulation of miR-375 leads to the attenuation of …

Eupatilin prevents behavioral deficits and dopaminergic neuron degeneration in a Parkinson's disease mouse model

Y Zhang, L Qin, J Xie, J Li, C Wang - Life sciences, 2020 - Elsevier
… and apoptosis play a crucial role in Parkinson's disease (PD) … Nuclear factor-κB (NF-κB)
signaling is one of the major mediators in … Anyway, Eupatilin attenuated the increased apoptosis. …

Astaxanthin suppresses endoplasmic reticulum stress and protects against neuron damage in Parkinson's disease by regulating miR-7/SNCA axis

DF Shen, HP Qi, C Ma, MX Chang, WN Zhang… - Neuroscience …, 2021 - Elsevier
… -7 mimics transfection could remarkably attenuate the luciferase … SNCA upregulation promoted
MPP+ induced cell apoptosis, … , we demonstrated that cell apoptosis was higher in MPTP …

Neuroprotective effects of catechin and quercetin in experimental Parkinsonism through modulation of dopamine metabolism and expression of IL-1β, TNF-α, NF-κB …

SS Josiah, CD Famusiwa, OO Crown, AO Lawal… - Neurotoxicology, 2022 - Elsevier
… While administration of catechin produced a more pronounced attenuating effect … upregulation
of inflammatory mediators such as IL-1β, TNF-α, NF-κB, and IκKB to initiate the apoptotic

NLRP3 Inflammasomes in Parkinson's disease and their Regulation by Parkin

YQ Yan, Y Fang, R Zheng, JL Pu, BR Zhang - Neuroscience, 2020 - Elsevier
… release of pro-inflammatory mediators and decreased secretion of … , such as upregulation
of pro-apoptotic protein such as BCL2 … Paeoniflorin from Paeoniae alba Radix also attenuates

NF-κB-mediated neuroinflammation in Parkinson's disease and potential therapeutic effect of polyphenols

SS Singh, SN Rai, H Birla, W Zahra, AS Rathore… - Neurotoxicity …, 2020 - Springer
mediator of neuroinflammation and ultimately cause the degeneration of the DA neurons …
Major unfavorable neuronal apoptosis is due to complex I deficiencies of the electron transport …

MicroRNA-216a inhibits neuronal apoptosis in a cellular Parkinson's disease model by targeting Bax

X Yang, M Zhang, M Wei, A Wang, Y Deng… - Metabolic Brain …, 2020 - Springer
… Studies have shown that Bax is strongly upregulated in nigrostriatal DA neurons after exposure
to … miR-216a attenuated MMP + -induced neuronal apoptosis by modulating Bax. These …

Lipids nutrients in Parkinson and Alzheimer's diseases: cell death and cytoprotection

T Nury, G Lizard, A Vejux - International Journal of Molecular Sciences, 2020 - mdpi.com
… This oil attenuates apoptosis by acting on calcium influx and … fibrillary acidic protein
upregulation, characteristic processes … in the levels of specialized protective mediators, involved in …