… overall mechanism of functional closure of the ductus involves a drop in PGE 2 levels after
birth, which impairs ductal … in preterm newborns may contribute to paracetamol-induced ductal …

… Results: Of the 43 infants, 25 were treated with acetaminophen … PDA closure rate was
slightly lower for acetaminophen … PDA closure with acetaminophen, all infants treated with …

… The ductus arteriosus is a fetal vascular channel … neonates, the ductus arteriosus may
persist beyond the immediate neonatal transitional period. A persistent patent ductus arteriosus (…

… of hemodynamically significant patent ductus arteriosus in preterm infants: a systematic …
Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low birth weight infants. …

… They are known to play an important role in keeping the ductus arteriosus open (or 'patent'),
so lowering their production would encourage closure of the ductus arteriosus. …

… Although we did not achieve immediate posttreatment acetaminophen closure in any
infants in our cohort, several had improved hemodynamic significance deemed by the medical …

… I, There was no significant difference in the ductal closure … to 1.05], the accumulated ductal
closure rate after two course of … treatment with oral acetaminophen versus oral ibuprofen (p > …

… acetaminophen for the treatment of a PDA in preterm infants. … mechanism of action of
acetaminophen for ductal closure … via prostaglandin H 2 (PGH 2 ) synthetase (PGHS) (Fig 2). …

… However, paracetamol is an alternative choice … paracetamol's efficacy and safety compared
with those of other drugs or placebos for patent ductus arteriosus closure in premature infants…

… The ability of acetaminophen to inhibit various forms of NOS (… actions (analgesic effects,
ductus arteriosus closure etc.), but … also for ductus arteriosus closure in preterm newborns. The …