Molecular mechanisms of inflammasome in ischemic stroke pathogenesis

MG Puleo, S Miceli, T Di Chiara, GM Pizzo… - Pharmaceuticals, 2022 - mdpi.com
… one of the leading actors of innate immunity responsible for the host’s response to the insult
of bacterial and viral infectious agents, inhibiting it in the acute stroke phase could make the …

Role of NLRP3 Inflammasome in Pathogenesis of Ischemic Stroke

SD Kazakov, EM Kamenskih, EV Udut - … Biochemistry and Physiology, 2024 - Springer
… The NLRP3 inflammasome emerges as a key mediator … activation process of the NLRP3
inflammasome in IS. The factors … about the role of MAMs in NLRP3 inflammasome activation. …

The role of selected pro-inflammatory cytokines in pathogenesis of ischemic stroke

H Pawluk, A Woźniak, G Grześk… - … interventions in aging, 2020 - Taylor & Francis
… the role of pro-inflammatory cytokines in acute stroke. Detailed analysis of their role in cerebral
… Intracellular multiprotein complexes called inflammasomes play an important role in the …

Relevant mediators involved in and therapies targeting the inflammatory response induced by activation of the NLRP3 inflammasome in ischemic stroke

Q Xu, B Zhao, Y Ye, Y Li, Y Zhang, X Xiong… - Journal of …, 2021 - Springer
… the clinical treatment of ischemic stroke. Understanding the NLRP3 inflammasome may provide
… in the NLRP3 pathway shows promise for ischemic stroke therapy. In this manuscript, we …

[引用][C] Ischemic stroke pathogenesis: genetics, epigenetics and inflammation

A Tuttolomondo - Current pharmaceutical design, 2020 - ingentaconnect.com
… injury occurring after stroke or a rupture of … pathogenesis of stroke and atherosclerosis. Also
discussed here are the possible treatment strategies available for inhibiting inflammasomes

Temporal and spatial dynamics of inflammasome activation after ischemic stroke

D Lu, M Hu, B Zhang, Y Lin, Q Zhu, X Men, Z Lu… - Frontiers in …, 2021 - frontiersin.org
… of inflammasome activation might indicate detrimental stroke … Post-stroke inflammasome
activation, especially NLRP3, … inflammasome played a prominent role in the pathogenesis

The inflammasome in stroke

JP de Rivero Vaccari, B Cyr - Inflammasome Biology, 2023 - Elsevier
pathophysiology of stroke, how different inflammasomes such as the NLRP1, NLPR3, AIM2,
and NLRC4 inflammasomes … -18 as well as the inflammasome-mediated cell death process …

NLRP3 inflammasome activation after ischemic stroke

PP Han, Y Han, XY Shen, ZK Gao, X Bi - Behavioural Brain Research, 2023 - Elsevier
… The etiology of stroke is … 3 inflammasome. The inflammation is aggravated by the
subsequent occurrence of pyroptosis. The mechanisms that activate the NLRP3 inflammasome

Pyroptosis in stroke-new insights into disease mechanisms and therapeutic strategies

X Gou, D Xu, F Li, K Hou, W Fang, Y Li - Journal of physiology and …, 2021 - Springer
pathology of stroke, the molecular mechanism, and process of pyroptosis, as well as the pivotal
roles of pyroptosis in strokeInflammasomes are a crucial target for the treatment of stroke. …

Role of NLRP3 Inflammasome in Stroke Pathobiology: Current Therapeutic Avenues and Future Perspective

K Panbhare, R Pandey, C Chauhan… - ACS Chemical …, 2023 - ACS Publications
inflammasome-mediated neuroinflammation following stroke. Additionally, we critically …
the role of the NLRP3 inflammasome-mediated signaling in stroke pathophysiology and the …