… Genetic analysis has indicated the involvement of several genes in the etiology of … However,
the association between glucocorticoid resistance and these genes remains unclear. Here, …

… the inheritance pattern implies a genetic etiology … genes are part of the mTOR/PI3K/Akt
pathway that regulates cell growth and proliferation [46]. Of note, few cases of corticotropinomas …

… Cushing syndrome refers to the clinical manifestations caused by excess chronic exposure
to glucocorticoids (Gc). Endogenous Cushing syndrome is … 80% of Cushing syndrome and, of …

… The primary treatment for Cushing’s disease is surgical … Three main factors are involved in
the etiology of Cushing’s disease: … on the molecular and genetic causes of Cushing’s disease. …

… Pathogenic variants in other genes are less common and can be associated with specific
phenotypes and clinical courses. Here, we review the current knowledge on the …

… Etiology of Cushing's disease … Further exome-sequencing studies looking for driver
mutations have revealed additional infrequent genetic alterations in corticotroph adenomas, …

… tests, imaging, and treatment options are presented, along with algorithms for diagnosis
of Cushing's syndrome and management of Cushing's disease. Topics considered most …

… Molecular mechanisms and genetic alterations associated with … to update several important
aspects of diagnosis, complications, and treatment of endogenous Cushing's syndrome of all …

… Treatment of Cushing’s disease mostly relies … pathophysiology of this disease. This review
aims to present the most recent updates on genetic mutations underlying Cushing’s disease. …

… , USP48, and BRAF genes may subsequently cause overexpression … approach, and provides
an update of the potential novel … understand CT origin and pathophysiology. This may also …