How I treat pediatric acute myeloid leukemia

JE Rubnitz, GJL Kaspers - Blood, The Journal of the American …, 2021 - ashpublications.org
… Treatment outcomes for pediatric patients with acute myeloid leukemia (AML) have continued
to lag behind outcomes reported for children with acute lymphoblastic leukemia (ALL), in …

Cytogenetics of pediatric acute myeloid leukemia: a review of the current knowledge

J Quessada, W Cuccuini, P Saultier, M Loosveld… - Genes, 2021 - mdpi.com
Pediatric acute myeloid leukemia is a rare and … current WHO classification of acute myeloid
leukemia, where there … an updated review of cytogenetics in pediatric AML, describing well-…

Pediatric acute myeloid leukemia—past, present, and future

D Reinhardt, E Antoniou, K Waack - Journal of clinical medicine, 2022 - mdpi.com
… This review reports about the main steps of development in pediatric acute myeloid
leukemia (AML) concerning diagnostics, treatment, risk groups, and outcomes. Finally, a …

A new genomic framework to categorize pediatric acute myeloid leukemia

M Umeda, J Ma, T Westover, Y Ni, G Song… - Nature Genetics, 2024 - nature.com
… Recent studies on pediatric acute myeloid leukemia (pAML) have revealed pediatric-specific
driver alterations, many of which are underrepresented in the current classification schemas…

Pediatric relapsed acute myeloid leukemia: a systematic review

AE Hoffman, LJ Schoonmade… - Expert review of …, 2021 - Taylor & Francis
Introduction: Pediatric relapsed acute myeloid leukemia (AML) remains lethal in the majority
of cases, despite intensive therapy. Randomized trials are largely lacking, and the main …

Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia

BJ Huang, JL Smith, JE Farrar, YC Wang… - Nature …, 2022 - nature.com
… Relapsed or refractory pediatric acute myeloid leukemia (AML) is … for pediatric AML, we
perform RNA-sequencing on 1503 primary diagnostic samples. While a 17 gene leukemia stem …

Single-cell analysis reveals altered tumor microenvironments of relapse-and remission-associated pediatric acute myeloid leukemia

H Mumme, BE Thomas, SS Bhasin, U Krishnan… - Nature …, 2023 - nature.com
Acute myeloid leukemia (AML) microenvironment exhibits … (scRNA-seq) to analyze pediatric
AML bone marrow (BM) samples … Altogether, this study deeply characterizes pediatric AML …

Integrated Genomic Analysis Identifies UBTF Tandem Duplications as a Recurrent Lesion in Pediatric Acute Myeloid Leukemia

M Umeda, J Ma, BJ Huang, K Hagiwara, T Westover… - Blood cancer …, 2022 - AACR
pediatric acute myeloid leukemia (AML) has yet to be comprehensively defined. Here, we
present the spectrum of genomic alterations in 136 relapsed pediatric … de novo pediatric AMLs, …

Molecular-targeted therapy of pediatric acute myeloid leukemia

P Obszański, A Kozłowska, J Wańcowiat… - Molecules, 2022 - mdpi.com
Acute myeloid leukemia (AML) accounts for approximately 15–20% of all childhood leukemia
cases. The overall survival of children with acute myeloid leukemia does not exceed 82%, …

Long noncoding RNA expression independently predicts outcome in pediatric acute myeloid leukemia

JE Farrar, JL Smith, M Othus, BJ Huang… - Journal of Clinical …, 2023 - ascopubs.org
… Iterative refinements in risk stratification have been a cornerstone for improved outcomes
in children with leukemia. The criteria used in stratifying pediatric acute myeloid leukemia (…