… structure of membrane-inserted perforin pore at near-atomic resolution. In combination with
a previously solved crystal structure of the soluble perforin … to membrane insertion of perforin. …

… Isolation and biochemical and functional characterization of perforin 1 from cytolytic T-cell
granules. Proc Natl Acad Sci USA (1985) 82(24):8629–33. doi: 10.1073/pnas.82.24.8629 …

… and the lack of knowledge on perforin structure, alternative hypothesis of … perforin and
Gzms are endocytosed into endosomal compartments of target cells and subsequently perforin …

… Indeed analyses across taxa and gene families suggest Mpeg1 is the ancestor of Perforin-1 …
Perforin-2 research with an emphasis on its expression and function within phagocytic cells. …

… Loss of perforin-2 renders individual … of perforin-2 activation and activity using atomic
structures of pre-pore and pore assemblies, high-speed atomic force microscopy, and functional …

… perforin in medicine. The rationale of this article is to conduct further research about the role
and use of perforin … to motivate for further research and education about the role of perforin. …

… After translational proper protein folding is a key to perform a functional role for a protein
in an organism. We predicted the 3D structure of GmMACPFs and found that all of the family …

… ions than that of human perforin. This was … perforin, which is replaced by arginine in human
perforin. This represents an additional mechanism to control the activity of human perforin. …

… Given that the binding pocket residues are conserved between mouse and human
perforin, our structural data also supported the identification of 1 as a candidate for further …

… and characterization of the perforin gene have also been … on the presence and function
of perforin in non-mammalian … mature perforin molecules consist of three structural domains…