[PDF][PDF] Permeabilized cryopreserved human hepatocytes as an exogenous metabolic system in a novel
H Wei, AP Li - researchgate.net
We report here a novel in vitro experimental system, the metabolism-dependent cytotoxicity
assay (MDCA), for the definition of the roles of hepatic drug metabolism in toxicity. MDCA
employs permeabilized cofactor-supplemented cryopreserved human hepatocytes
(MetMax™ human hepatocytes, MMHH), as an exogenous metabolic activating system, and
HEK-293 cells, a cell line devoid of drug metabolizing enzyme activity, as target cells for the
quantification of drug toxicity. The assay was performed in the presence and absence of …
assay (MDCA), for the definition of the roles of hepatic drug metabolism in toxicity. MDCA
employs permeabilized cofactor-supplemented cryopreserved human hepatocytes
(MetMax™ human hepatocytes, MMHH), as an exogenous metabolic activating system, and
HEK-293 cells, a cell line devoid of drug metabolizing enzyme activity, as target cells for the
quantification of drug toxicity. The assay was performed in the presence and absence of …
Permeabilized cryopreserved human hepatocytes as an exogenous metabolic system in a novel metabolism-dependent cytotoxicity assay for the evaluation of …
H Wei, AP Li - Drug Metabolism and Disposition, 2022 - ASPET
We report here a novel in vitro experimental system, the metabolism-dependent cytotoxicity
assay (MDCA), for the definition of the roles of hepatic drug metabolism in toxicity. MDCA
employs permeabilized cofactor-supplemented cryopreserved human hepatocytes (MetMax
Human Hepatocytes, MMHH), as an exogenous metabolic activating system, and human
embryonic kidney 293 (HEK293) cells, a cell line devoid of drug-metabolizing enzyme
activity, as target cells for the quantification of drug toxicity. The assay was performed in the …
assay (MDCA), for the definition of the roles of hepatic drug metabolism in toxicity. MDCA
employs permeabilized cofactor-supplemented cryopreserved human hepatocytes (MetMax
Human Hepatocytes, MMHH), as an exogenous metabolic activating system, and human
embryonic kidney 293 (HEK293) cells, a cell line devoid of drug-metabolizing enzyme
activity, as target cells for the quantification of drug toxicity. The assay was performed in the …
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