More than addiction—The nucleus accumbens contribution to development of mental disorders and neurodegenerative diseases

M Bayassi-Jakowicka, G Lietzau, E Czuba… - International journal of …, 2022 - mdpi.com
chronic stress and morphological changes to the structure of … and reduction of BDNF levels
in the frontal cortex [77,78] and … a decrease in the amount of DA produced in the VTA. Studies …

… Ventral Tegmental Area (VTA), the Nucleus Accumbens (NAc), the Caudate Nucleus (CN) and the Prefrontal Cortex (PFC) role in the Response to Acute and Chronic …

N King, N Dafny - Journal of Experimental Neurology, 2023 - scientificarchives.com
… , while chronic use of MPD has been reported to produce behavioral … the diverse neuronal
populations in the PFC [11,14] … to the PFC are mixed: with some reporting behavioral changes

[HTML][HTML] Histone H3 dopaminylation in nucleus accumbens, but not medial prefrontal cortex, contributes to cocaine-seeking following prolonged abstinence

AF Stewart, AE Lepack, SL Fulton, P Safovich… - Molecular and Cellular …, 2023 - Elsevier
… innervation from VTA, with alterations in these inputs in response … within these brain structures
following chronic cocaine exposures… The RNA-seq data generated in this study have been …

Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens

BL Thompson, M Oscar-Berman, GB Kaplan - … & Biobehavioral Reviews, 2021 - Elsevier
… In particular, structural and functional alterations in the … Additionally, glutamatergic neurons
from the prefrontal cortex, … in part, of persistent drug-induced structural and functional synaptic …

Dopamine-mediated major depressive disorder in the neural circuit of ventral tegmental area-nucleus accumbens-medial prefrontal cortex: from biological evidence to …

Y Li, B Zhang, X Pan, Y Wang, X Xu… - Frontiers in Cellular …, 2022 - frontiersin.org
… membrane potential changes of dopaminergic neurons in the … persistent sodium channel
of the pyramidal neurons in PFC, … article, or claim that may be made by its manufacturer, is not …

Neuroplasticity and multilevel system of connections determine the integrative role of nucleus accumbens in the brain reward system

M Bayassi-Jakowicka, G Lietzau, E Czuba… - International Journal of …, 2021 - mdpi.com
… the level of activity of the prefrontal cortex, by modifying the … of changes in myelin structure
in consequence of chronic … reaction generated in NAc is determined by the pattern of neuronal

Phenylbutyrate ameliorates prefrontal cortex, hippocampus, and nucleus accumbens neural atrophy as well as synaptophysin and GFAP stress in aging mice

FN Carvajal‐Flores, A Díaz, GD Flores‐Gómez… - Synapse, 2020 - Wiley Online Library
… PBA did not modify locomotive activity in a novel environment in the old mice, despite producing
an … Interestingly, our results suggest that the chronic administration of PBA increases the …

[HTML][HTML] Transcriptional alterations in dorsolateral prefrontal cortex and nucleus accumbens implicate neuroinflammation and synaptic remodeling in opioid use …

ML Seney, SM Kim, JR Glausier, MA Hildebrand… - Biological …, 2021 - Elsevier
… of molecular alterations due to chronic opioid use and OUD … Focusing on transcript
expression in neurons, we identified … , with the network structure generated on each brain region …

Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens

AK Zinsmaier, Y Dong, YH Huang - Molecular psychiatry, 2022 - nature.com
… -induced adaptive changes in the brain reward circuits. The … from the medial prefrontal cortex,
basolateral amygdala, ventral … which cocaine experience produces persistent synaptic and …

Prefrontal Cortical Control of Activity in Nucleus Accumbens Core Is Weakened by High-Fat Diet and Prevented by Co-Treatment with N-Acetylcysteine: Implications …

C Morgan, P Sáez-Briones, R Barra, A Reyes… - International Journal of …, 2022 - mdpi.com
… of HFD can lead to neuroplastic changes an addiction-like … that rats treated with chronic
cocaine displayed significant … and 0.2 Hz in frequency, generated by a Grass S11 stimulator in …