Elevated cochlear adenosine causes hearing loss via ADORA2B signaling
J Manalo - 2020 - digitalcommons.library.tmc.edu
… due to their variable distribution of expression in different cell … of adenosine signaling in inner
ear physiology and help treat … the external canal of the mouse ear that were elicited by two …
ear physiology and help treat … the external canal of the mouse ear that were elicited by two …
Viral vectors, animal models, and cellular targets for gene therapy of cystic fibrosis lung disease
Y Tang, Z Yan, JF Engelhardt - Human gene therapy, 2020 - liebertpub.com
… required for ionocyte specification in mouse, human, and … , a hybrid piggyBac/adenovirus
vector can highly transduce … on the development of effective gene delivery systems. Thus, …
vector can highly transduce … on the development of effective gene delivery systems. Thus, …
Of rAAV and men: from genetic neuromuscular disorder efficacy and toxicity preclinical studies to clinical trials and back
L Buscara, DA Gross, N Daniele - Journal of Personalized Medicine, 2020 - mdpi.com
… for the delivery of genes in neuromuscular tissues is derived … -body delivery of an
rAAV2/8-Des-mtm1 product in mouse and … lethal systemic inflammation with an adenovirus vector …
rAAV2/8-Des-mtm1 product in mouse and … lethal systemic inflammation with an adenovirus vector …
A Transgenic Rat for Noninvasive Assessment of Chondrogenesis in Vivo
E Ferreira, LB Gatrell, L Childress, H Wu… - Cartilage, 2021 - journals.sagepub.com
… conditional expression within multiple transgenic mouse strains… at the injection site within 4
weeks of adenovector delivery, as … ongoing efforts within the skeletal tissue engineering and …
weeks of adenovector delivery, as … ongoing efforts within the skeletal tissue engineering and …
Emerging Therapies and Approaches to Treat and Prevent Hearing Loss
A Koleilat, CLW Driscoll, LA Schimmenti… - Perspectives of the ASHA …, 2020 - ASHA
… dysfunction, eardrum perforation, tissue or bony growths (… The main routes of delivery to the
inner ear are injection into the … treat the mouse model of DFNB1 (GJB2-related hearing loss) …
inner ear are injection into the … treat the mouse model of DFNB1 (GJB2-related hearing loss) …
[HTML][HTML] Novel therapies for Alport syndrome
… long enough to resolve the reversible pharmacodynamic effect of bardoxolone and that the
… Reports of succesful delivery of COL4A5 gene into swine kidney with an adenovirus vector …
… Reports of succesful delivery of COL4A5 gene into swine kidney with an adenovirus vector …
Seeing the Future: A Review of Ocular Therapy
M Whalen, M Akula, SM McNamee, MM DeAngelis… - Bioengineering, 2024 - mdpi.com
… delivery systems and their applications, mechanisms for delivering therapeutic products to
ocular tissues… post-operative delivery of Sparc siRNA via nanoparticles in a mouse model of …
ocular tissues… post-operative delivery of Sparc siRNA via nanoparticles in a mouse model of …
[HTML][HTML] Mitochondrial dysfunction and sirtuins: important targets in hearing loss
L Zhang, Z Du, S Gong - Neural Plasticity, 2021 - hindawi.com
… A suitable model of the senescence-accelerated mouse prone … Pretreatment with an
adenovector expressing human Bcl-2 (… of noise exposure, reduces inner ear blood flow,” …
adenovector expressing human Bcl-2 (… of noise exposure, reduces inner ear blood flow,” …
Sustained correction of a murine model of phenylketonuria following a single intravenous administration of AAVHSC15-PAH
SS Ahmed, H Rubin, M Wang, D Faulkner… - … Therapy-Methods & …, 2020 - cell.com
… A second study was performed using a group of six male mice dosed at 2 × 10 12 VG/mouse
with AAVHSC15-CBA-PAH to examine hepatic transduction, human PAH expression, and …
with AAVHSC15-CBA-PAH to examine hepatic transduction, human PAH expression, and …
High-capacity adenoviral vectors: expanding the scope of gene therapy
A Ricobaraza, M Gonzalez-Aparicio… - International Journal of …, 2020 - mdpi.com
… The adaptation of adenoviruses as gene delivery tools has … but the interplay between cellular,
tissue, and systemic factors … full protection from hyperammonemia in a mouse model [144]. …
tissue, and systemic factors … full protection from hyperammonemia in a mouse model [144]. …