… optimal dose of clonidine and midazolam in the PICU (CloSed … an IV dose of 2 µg/kg for
procedural pain in preterm infants. … fentanyl, clonidine and midazolam were defined in specific …

… Absorption In the early phase of their critical care, the intravenous route ensures full drug …
for the objective and continuous evaluation of respiration and drug effects in preterm infants. …

… including pharmacokinetics/pharmacodynamics, and … intravenously or orally, and it was
initially used to treat neonatal opioid abstinence [26]. Clonidine reduces fentanyl and midazolam …

… be well-versed with the principles of pharmacology, drug dosages… for use in neonates and
none for preterm neonates born before 30 … Intravenous use can lead to hypotension and is not …

… useful in very preterm infants, partially useful in older preterm infants, and useful in full-term
infants. … Intravenous bolus of midazolam in neonates has been associated with hypotension; …

… Case Presentation − We report myoclonic seizure-like abnormal activity in four preterm
neonates, who received intravenous midazolam for sedation before laser photocoagulation for …

… Pharmacodynamics of 263 intravenous and oral midazolam in preterm infants. Clin Drug …
Rhythmic myoclonic jerking induced by 285 midazolam in a preterm infant. Pediatr Neurol. …

… of all neonates and 88.0% of preterm neonates born before … We can assume that drugs
prescribed as single intravenous … , fentanyl, and midazolam: usually lower doses for lower GA. …

… PK-Sim® (Open Systems Pharmacology) and Simcyp® (Certara)… of midazolam and 1-OH-midazolam
profiles following IV or oral … midazolam metabolism in preterm neonates [Citation35] …

… than 14 days, clonidine may facilitate weaning or transition from intravenous to oral therapy.
… Furthermore, there is a lack of pharmacokinetic data on DEX in preterm infants; therefore, …