A rational approach to determine a safe and effective dose in an individual child necessitates
understanding the pharmacokinetic (PK) and pharmacodynamic (PD) properties of a given …

… among preterm neonates receiving a sulphonamide antibiotic as compared to neonates
receiving … For instance, when administered intravenously, midazolam clearance reflects hepatic …

… fentanyl, midazolam, or lorazepam was associated with lower BSID-III scores compared with
infants without … In contrast, BSID-III scores for infants with short exposure to both opioids and …

… in NeOnates (DINO) study, in which preterm neonates born … of 2.5 mg/kg was administered
intravenously over 15 min at … A drug-drug interaction can also be of a pharmacodynamic (…

… for dental extractions where a technique using oral midazolam … This study provides further
evidence for the safety profile of iv … and pharmacodynamics in neonates, infants, and in …

… is delayed in preterm infants compared with term infants and … with oral clonidine was superior
to oral midazolam, since oral … of patients have altered pharmacodynamic response to BZDs…

… anatomy and physiology as well as anesthetic pharmacology is essential for the provider
caring … The patient should be given intravenous famotidine and oral sodium citrate before the …

… of distribution in preterm infants than in older infants. Preterm infants also have greater …
is 0.8 L/kg, 20 mg/L is the desired concentration, and F for an IV dose is assumed to be 1, a …

… event in both term and preterm newborn infants and can be … hours in preterm infants,
decreasing to 67 hours in infants at … data from both intravenous (IV) and oral administration. …

… of full-term neonates versus only 55% of preterm neonates. 55 … be more efficacious than
midazolam, but larger prospective … a neonate developing anaphylactic shock after 10 mg/kg of IV …