Population Pharmacodynamic Modelling of the CD19+ Suppression Effects of Rituximab in Paediatric Patients with Neurological and Autoimmune Diseases

N Riva, L Brstilo, A Sancho-Araiz, M Molina… - Pharmaceutics, 2023 - mdpi.com
… pathologies in children lead to increased off-label use of rituximab. We … B lymphocytes (CD19+)
under treatment with intravenous rituximab in children with neurologic and autoimmune

[PDF][PDF] Paediatric rheumatology Anti-rituximab antibodies affect pharmacokinetics and pharmacodynamics of rituximab in children with immune-mediated diseases

…, SC Gouw, TW Kuijpers, T Rispens… - Clinical and …, 2022 - researchgate.net
… Pharmacodynamics of rituximab on B lymphocytes in paediatric patients with autoimmune
… antibodies in autoimmune disease treatment. Auto Immun Highlights 2017; 8: 12. 38. …

Rituximab pediatric drug development: pharmacokinetic and pharmacodynamic modeling to inform regulatory approval for rituximab treatment in patients with …

C Jamois, L Gibiansky, C Chavanne… - Clinical and …, 2022 - Wiley Online Library
autoimmune conditions affecting adult and pediatric patients. An … of rituximab in pediatric
patients with GPA/MPA. To determine the selection of an appropriate dose regimen in children

[PDF][PDF] Paediatric rheumatology Pharmacodynamics of rituximab in paediatric immune mediated diseases: B cell depletion and repopulation, effects on …

ANS Rashid, SC Bergkamp… - Clinical and …, 2023 - clinexprheumatol.org
… not significantly differ between paediatric patient groups. Severe … In other autoimmune
diseases, such as systemic lupus … B cell depletion has been reported in various adult patients (6, 7)…

Implications of rituximab pharmacokinetic and pharmacodynamic alterations in various immune-mediated glomerulopathies and potential anti-CD20 therapy …

JM Hartinger, V Kratky, Z Hruskova, O Slanar… - Frontiers in …, 2022 - frontiersin.org
… found rituximab to be effective for other autoimmune diseases … on all B-lineage cells other
than precursor B cells and … Pharmacokinetics of rituximab in a pediatric patient with therapy-…

A retrospective analysis of rituximab treatment for B cell depletion in different pediatric indications

M Wennmann, S Kathemann, K Kampmann… - … in Pediatrics, 2021 - frontiersin.org
autoimmune diseases and alloimmune responses after transplantation. It depletes the
disease-causing B cells … bone marrow transplantation, pediatric immunology and pharmacology. …

Use of rituximab in paediatric nephrology

R Sinha, N Agrawal, Y Xue, R Chanchlani… - … Disease in Childhood, 2021 - adc.bmj.com
… lineage including pre-B cells, memory cells and B lymphocytes found in tissues such …
Pharmacodynamics of rituximab on B lymphocytes in paediatric patients with autoimmune diseases

Rituximab in patients with pediatric multiple sclerosis and other demyelinating disorders of the CNS: practical considerations

…, B Banwell, A Bar-Or, T Chitnis… - Multiple Sclerosis …, 2021 - journals.sagepub.com
… evaluating the pharmacokinetic/pharmacodynamic activity of … rituximab a more affordable,
and potentially the only B cell-… , performed in pediatric patients with autoimmune disorders, …

… strategies of rituximab for pediatric patients with frequent-relapsing or steroid-dependent nephrotic syndrome: a prospective pharmacokinetic-pharmacodynamic study

Y Chen, Q Shen, Y Xiong, M Dong, H Xu… - … in Pharmacology, 2024 - frontiersin.org
… the effect of rituximab on eliminating B lymphocytes in the treatment of pediatric patients with
… dosing regimens that provide adequate suppression of B lymphocytes (below 10 × 10 6 /L) …

Development of anti-rituximab antibodies in rituximab-treated patients: Related parameters & consequences

F Saffari, A Jafarzadeh - Indian Journal of Medical Research, 2022 - journals.lww.com
… to T cells through interaction between the T cell receptor and … in rituximab-administered
patients with autoimmune diseases … , and pharmacodynamics between RTXM83™, a rituximab