… enzymes (CYP2D6, CYP3A4/5), which are implicated in the pharmacokinetics of opioids (22). …
Starting Step III opioids for moderate to severe pain in cancer patients: Dose titration: A …

… of pain, coupled with evolving pharmacokinetic and pharmacodynamic changes can make
assessment and management of acute pain and the use of opioids in the … , or optimisation of …

… Both hepatic and renal impairment can influence the pharmacokinetics of opioids beyond
a … The moderate-to-severe pain associated with cancer often requires increasing doses of …

… Opioid analgesia is effective for acute pain and pain at the end of life, but evidence for long-…
of changes in both pharmacodynamics and pharmacokinetics. Consequently, side effects of …

… However, if a patient is to get good pain relief and good outcomes from their acute pain
treatment… It is also possible that ongoing treatment of acute pain with opioids after discharge from …

… ; assessment of pain and opioid withdrawal; and treatment of acute pain with nonopioid …
infusions to optimize patient-specific pharmacokinetics and reducing sedative exposure. If …

… methadone’s use in acute pain management and both chronic cancer and non-cancer …
second-line opioid treatment for select chronic pain conditions. The complicated pharmacokinetic …

… studies to optimize oxycodone dosing … treated clinically with opioids for moderate-severe
pain were included, and in this setting, oxycodone is used less frequently than other opioids as …

… Pain management is complex, and opioids are often used in the treatment of chronic moderate
to severe pain… help explain variations and optimize treatment regimens. Pupillometry has …

… for moderate and severe pain during … opioid for perioperative pain in infants and children
followed by fentanyl. Although the benefit of opioids in preterm infants is clear for acute pain, its …