Background: Chronic obstructive pulmonary disease (COPD) is characterized by frequent
exacerbations. Purpose: To evaluate the comparative effectiveness and adverse events
(AEs) of pharmacologic interventions for adults with exacerbation of COPD. Data Sources:
English-language searches of several bibliographic sources from database inception to 2
January 2019. Study Selection: 68 randomized controlled trials that enrolled adults with
exacerbation of COPD treated in out-or inpatient settings other than intensive care and …

Objective To evaluate the effectiveness and adverse events of nonpharmacologic
interventions in patients with exacerbation of chronic obstructive pulmonary disease
(COPD). Patients and Methods We searched Embase, MEDLINE, Cochrane databases,
Scopus, and clinicaltrials. gov from database inception to January 2, 2019, for randomized
controlled trials that enrolled adults with exacerbation of COPD and evaluated the effect of
nonpharmacologic interventions on clinical outcomes and/or lung function. Results We …