… an update on the most recently published treatment guidelines for pharmacologic treatment
of PAH and incorporates them into a contemporary approach to the treatment of this disease. …

… Current treatment consists of combination drug therapy that targets more than 1 biological
… Practice guidelines recommend obtaining an echocardiogram in all patients with portal …

… guidelines and collective clinical experiences to navigate between pharmacologic and
interventional treatments, … techniques, non-pharmacologic therapies discussed in this section are …

… Pulmonary arterial hypertension pharmacotherapies by … Sotatercept is not US Food and
Drug Administration–approved; it … ERS guidelines for the diagnosis and treatment of pulmonary …

… all published RCTs of clinically relevant benefits of drug treatments for PAH over a median of
12… support current clinical practice guidelines recommendations for combination pulmonary …

… ), heritable PAH (group 1.2), drug- and toxin-induced PAH (… pulmonary arterial hypertension
(PAH)–approved therapies. … c Lung transplant is outside the scope of this guideline, which …

… pulmonary arterial hypertension (PAH), there are no data comparing initial triple oral therapy
with initial double oral therapy… SKILLS: During initial oral drug therapy for patients with PAH, …

… be shown to be beneficial, leading to a strategy similar to guideline directed medical therapy
in … Maximal medical therapy is now four-drug therapy; this is based on the sotatercept RCTs …

… therapy are relatively similar. Lifestyle adaptation is absolutely key in non-pharmacological
treatment… the use of single-pill combination therapy by most guidelines. As a fourth-line agent, …

… fact that PWV has high sensitivity to detect vascular changes induced by pharmacological
treatment [16,17]. Nevertheless, PWV is not considered a therapeutic target in any guidelines. …