Many roads lead to CASM: Diverse stimuli of noncanonical autophagy share a unifying molecular mechanism
… an important parallel role in “noncanonical” autophagy, a … and noncanonical autophagy
provide a clear pharmacological … V0-V1 binding is induced by stimuli that drive CASM (eg, CQ, …
provide a clear pharmacological … V0-V1 binding is induced by stimuli that drive CASM (eg, CQ, …
[HTML][HTML] Pharmacological insights into autophagy modulation in autoimmune diseases
… Autophagy activation drives RA development, which elicits discussions about the roles of …
and immune system regulation can be regulated in parallel by mTOR, whether the rapamycin-…
and immune system regulation can be regulated in parallel by mTOR, whether the rapamycin-…
Targeting autophagy in disease: established and new strategies
… role of autophagy in pathophysiology is being studied in parallel. … in autophagy-related drug
discovery and indicate a path … understanding the non-canonical roles of autophagy in tumor-…
discovery and indicate a path … understanding the non-canonical roles of autophagy in tumor-…
[PDF][PDF] Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine
J Durgan, AH Lystad, K Sloan, SR Carlsson, MI Wilson… - Molecular cell, 2021 - cell.com
… during non-canonical autophagy, a parallel pathway involving … Pharmacological activation
of non-canonical autophagy … upon activation of canonical (PP242/BafA1) and non-canonical …
of non-canonical autophagy … upon activation of canonical (PP242/BafA1) and non-canonical …
The coordination of V-ATPase and ATG16L1 is part of a common mechanism of non-canonical autophagy
Y Lei, DJ Klionsky - Autophagy, 2022 - Taylor & Francis
… may drive the … non-canonical autophagy activated by different types of stimuli, including
disrupting the lysosome ion balance and MCOLN1 activation, but not after canonical autophagy …
disrupting the lysosome ion balance and MCOLN1 activation, but not after canonical autophagy …
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy
KM Hooper, E Jacquin, T Li, JM Goodwin… - Journal of Cell …, 2022 - rupress.org
… Here, using pharmacological inhibitors, we investigate a role … diverse non-canonical
autophagy processes to drive CASM, … as a parallel host response. To explore a possible role for …
autophagy processes to drive CASM, … as a parallel host response. To explore a possible role for …
Molecular mechanism of autophagy and its regulation by cannabinoids in cancer
XC Lee, E Werner, M Falasca - Cancers, 2021 - mdpi.com
… Activation of protective autophagy by 5FU results in drug … Parallel inhibition of ERK
synergistically enhances HQL … the induction of a non-canonical autophagic-facilitated apoptotic …
synergistically enhances HQL … the induction of a non-canonical autophagic-facilitated apoptotic …
Lysosome damage triggers direct ATG8 conjugation and ATG2 engagement via non-canonical autophagy
… Here, we describe a parallel ATG8/LC3 response to lysosome … series of biochemical,
pharmacological, and genetic … that multiple autophagy-related pathways drive temporally and …
pharmacological, and genetic … that multiple autophagy-related pathways drive temporally and …
Activation of non-canonical autophagic pathway through inhibition of non-integrin laminin receptor in neuronal cells
A Limone, I Veneruso, A Izzo, M Renna, R Bonavita… - Cells, 2022 - mdpi.com
… Altogether, our data were supported and further strengthened by recent findings that other
pharmacological modulators of autophagy can activate a non-canonical pathway driving …
pharmacological modulators of autophagy can activate a non-canonical pathway driving …
Noncanonical autophagy is a new strategy to inhibit HSV-1 through STING1 activation
Z Zheng, M Zhao, H Shan, D Fang, Z Jin, J Tang, Z Liu… - Autophagy, 2023 - Taylor & Francis
… In the process of NCA, a parallel LC3 lipid pathway involves the conjugation of LC3 to a …
NCA induced by chemical AMDE-1 (autophagy modulator with dual effects) and osmotic stress …
NCA induced by chemical AMDE-1 (autophagy modulator with dual effects) and osmotic stress …