… It is estimated to cost more than 480 billion euros each year throughout the world (Sources:
OMS, EBC (European Brain Council)). Currently, no pharmacological treatment is available …

… Importance Malignant primary brain tumors cause more than 15 000 deaths per year in the
… incidence of primary malignant brain tumors is approximately 7 per 100 000 individuals and …

… common primary brain cancer in adults.… Depression can affect 1 in 5 patients with glioma.No
RCTs to date have investigated the efficacy of pharmacological treatments for depression …

… If the ISI score is greater than 15, discussion of pharmacologic treatment and non-pharmacologic
treatment with their PCP or referral to a sleep specialist is advised. Lastly, multiple …

… , 60–75% of patients with brain metastases will be symptomatic at … resemble those seen in
patients with primary brain tumors … up to 25% of patients Various drug combinations and doses …

… A cross-sectional analysis was undertaken in 78 primary brain tumour patients after RT.
Cognitive function was assessed by neuropsychological tests. Test scores were standardized …

… CPC participants reported significantly lower anxiety and depression at 2-week, 4-week
and 3-month post-discharge and better treatment compliance (eg, medication) at 12-month …

… Y as a treatment for mood and anxiety disorders, and on a patent pending for the use of
ezogabine and other KCNQ channel openers to treat depression and related conditions. The …

… -penetrant drug that potently inhibits SMPD1 for the treatment of patients with GBM. We …
studies revealing complete tumor regression in patient-derived GBM brain tumor models in mice …

… fact that 800,000 people die from suicide every year (1). Currently, due to the development
of pharmacological therapies, psychiatrists have the means to ‘rewire’ the brain's circuits in …