[HTML][HTML] Therapeutics for enhancement of spinal fusion: A mini review

Y Zhang, Y Jiang, D Zou, B Yuan, HZ Ke… - Journal of Orthopaedic …, 2021 - Elsevier
… In terms of systemic therapeutic approaches, the osteoporosis drug Teriparatide has played
a positive role in promoting bone healing after spinal surgery, while new medications such …

Medical optimization of osteoporosis for adult spinal deformity surgery: a state-of-the-art evidence-based review of current pharmacotherapy

AS Zhang, S Khatri, M Balmaceno-Criss, D Alsoof… - Spine Deformity, 2023 - Springer
… beneficial effects on improving bone mineral density in the osteoporotic patient, varying
evidence is available on their specific effects in the context of extensive spine surgery. There is …

[HTML][HTML] Pharmacologic and regenerative cell therapy for spinal cord injury: WFNS spine committee recommendations

T Takami, N Shimokawa, J Parthiban, M Zileli, S Ali - Neurospine, 2020 - ncbi.nlm.nih.gov
… field of neuro-spine surgery. Although clinical management of … trial of the safety,
pharmacokinetics, and preliminary trial of … adult cell sources such as bone marrow stem cells, …

Population pharmacokinetics of cefuroxime and uptake into hip and spine bone of patients undergoing orthopaedic surgery

U Gergs, L Becker, R Okoniewski… - Journal of Pharmacy …, 2020 - academic.oup.com
… penetrated poorly into bone. [11] In the present work, we studied cancellous bone and the
cortical bone of hip and bone and intervertebral discs from spine surgery patients and asked …

Spinal fusion surgery and local antibiotic administration: a systematic review on key points from preclinical and clinical data

S Maria, C Deyanira, S Francesca, M Lucia… - Spine, 2020 - journals.lww.com
… The addition of iliac crest bone graft restored the fusion capability of the graft while reducing
the … Here, pharmacokinetics and the safety of vancomycin powder administration at different …

Narrative Review of Antiplatelet and Anticoagulant Medications for Venous Thromboembolism Prevention in Spine Surgery

PK Louie, H Urakawa, MK Manzur, CM Craig… - … Spine Surgery, 2022 - journals.lww.com
… A MEDLINE query identified literature reporting on VTE prevention and outcomes in the
setting of spine surgery. Findings extracted from the included articles were summarized in a …

Postoperative pain management in pediatric spinal fusion surgery for idiopathic scoliosis

CS Lee, S Merchant, V Chidambaran - Pediatric Drugs, 2020 - Springer
… Concern about bone formation/healing has been fueled by delayed bone healing in animal
… of spinal fusion, celecoxib did not. The authors postulated this was because bone healing …

Physiologically based population pharmacokinetic modeling approach for ciprofloxacin in bone of patients undergoing orthopedic surgery

CB Landersdorfer, M Kinzig, R Höhl… - ACS Pharmacology & …, 2020 - ACS Publications
… cortical bone, and cancellous bone via measuring the concentrations of ciprofloxacin in bone
and plasma from a cohort of patients who had received the drug prior to orthopedic surgery

[PDF][PDF] Osteoporosis Management: A Suggested Algorithm for Optimizing Spine Surgery Outcomes in Osteoporotic Patients

B Luck-Wold, MC Findlay, KL Cole… - Clinical Trials and …, 2023 - clinicsearchonline.org
… Regarding the epidemiology of the two bone diseases in spine surgery, there appears to be
a … on the effects of decreased bone density and outcomes after spine surgery. However, in …

The association of preoperative TNF-alpha inhibitor use and reoperation rates in spinal fusion surgery

MA Gaudiani, RD Winkelman, P Ravishankar… - The Spine Journal, 2021 - Elsevier
… and subsequent bone healing [23]. In spinal fusion patients, bone healing is essential to a
successful … Studies on the pharmacokinetics of infliximab, a commonly used TNF-AI, show an …