A phase 1b study of the MET inhibitor capmatinib combined with cetuximab in patients with MET-positive colorectal cancer who had progressed following anti-EGFR …

JP Delord, G Argilés, J Fayette, L Wirth, S Kasper… - Investigational New …, 2020 - Springer
… to anti-epidermal growth factor receptor (EGFR) monoclonal … In this phase 1b multicenter,
open-label, dose-finding study (… phase 2 dose of 400 mg that had previously been selected in …

[HTML][HTML] … with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial

V Subbiah, EI Dumbrava, Y Jiang, KZ Thein… - … hematology & oncology, 2020 - Springer
… A triplet combination of epidermal growth factor receptor (EGFR) monoclonal antibody and
… The dose-escalation portion of the study determined the recommended phase II dose (RP2D…

[HTML][HTML] A randomized phase II study comparing the efficacy and safety of the glyco-optimized anti-EGFR antibody tomuzotuximab against cetuximab in patients with …

K Klinghammer, J Fayette, A Kawecki, A Dietz… - ESMO open, 2021 - Elsevier
… the addition of the epidermal growth factor receptor (EGFR) antibody cetuximab to a cisplatin
… The RESGEX study was a phase II, randomized, controlled, open-label, multicenter study of …

… phase 2 study of temsirolimus and cetuximab versus temsirolimus alone in recurrent/metastatic, cetuximab‐resistant head and neck cancer: The MAESTRO study

TY Seiwert, S Kochanny, K Wood, FP Worden… - Cancer, 2020 - Wiley Online Library
… This study hypothesized that dual blockade of mammalian target of rapamycin and epidermal
growth factor receptor (… In this multicenter, randomized clinical study, patients with recurrent/…

[HTML][HTML] Implementing anti-epidermal growth factor receptor (EGFR) therapy in metastatic colorectal cancer: challenges and future perspectives

E Martinelli, D Ciardiello, G Martini, T Troiani… - Annals of …, 2020 - Elsevier
Epidermal growth factor receptor (EGFR) inhibitors are … Anti-EGFR monoclonal antibodies
(MoAbs), such as cetuximab or … VELO is a multicenter randomized phase II trial which is …

Phase II multi-institutional clinical trial result of concurrent cetuximab and nivolumab in recurrent and/or metastatic head and neck squamous cell carcinoma

CH Chung, J Li, CE Steuer, P Bhateja, M Johnson… - … Cancer Research, 2022 - AACR
… conducted a phase II multi-institutional clinical trial to determine … treated with a combination
of cetuximab and nivolumab. In … Open-label, uncontrolled, multicenter phase II study to …

Randomized Trial of Afatinib Plus Cetuximab Versus Afatinib Alone for First-Line Treatment of EGFR-Mutant Non–Small-Cell Lung Cancer: Final Results From SWOG …

SB Goldberg, MW Redman, R Lilenbaum… - Journal of Clinical …, 2020 - ascopubs.org
… were enrolled in this phase II, multicenter trial and randomly assigned to receive afatinib
40 mg orally daily plus cetuximab 500 mg/m 2 intravenously every 2 weeks or afatinib alone. …

[HTML][HTML] Anti-epidermal growth factor receptor (EGFR) monoclonal antibody combined with chemoradiotherapy for induction chemotherapy resistant locally advanced …

X Niu, P Liu, X Zhou, D Ou, X Wang, C Hu - Translational Oncology, 2024 - Elsevier
… [15] demonstrated that adding cetuximab to CCRT did not improve outcome for stage III to IV
… So, we designed a single-arm, open-label phase II clinical trial investigating the efficacy and …

[HTML][HTML] Phase II study of biweekly cetuximab plus mFOLFOX6 or mFOLFIRI as second-line treatment for metastatic colorectal cancer and exploratory analysis of …

S Takahashi, K Ouchi, Y Sakamoto, T Mori… - Journal of …, 2023 - ncbi.nlm.nih.gov
… from the anti-epidermal growth factor receptor (EGFR) antibody treatment. The purpose of
this study was to examine the efficacy and safety of biweekly cetuximab plus mFOLFOX6 or …

[HTML][HTML] CAVE-2 (Cetuximab-AVElumab) mCRC: a phase II randomized clinical study of the combination of avelumab plus cetuximab as a rechallenge strategy in pre …

S Napolitano, G Martini, D Ciardiello, M Di Maio… - Frontiers in …, 2022 - frontiersin.org
… Anti-epidermal growth factor receptor (EGFR) monoclonal … -arm, multi-center phase II study
of cetuximab plus avelumab … with cetuximab (400 mg/m 2 and, subsequently, 250 mg/m 2