… application was more effective for pharmacokinetic analysis than … Midazolam is a substrate
of the CYP3A4 isoenzyme, which is … of asphyxia on phenobarbital pharmacokinetics is likely …

… systematic literature search on neonatal pharmacokinetic (PK) and/… PK/PD of phenobarbital
in term asphyxiated neonates. To … PK and PD related) drug-drug interactions. Multicenter and …

… of the magnitude of drug-drug interaction across studies was … Midazolam is a substrate of
CYP3A4 which is not associated … that administration of phenobarbital to asphyxiated newborns …

… use of other antiepileptic medications, including phenobarbital ( 22 ). Although our …
Phenobarbital, midazolam pharmacokinetics, effectiveness, and drug-drug interaction in asphyxiated …

… is effective in 91% of the patients where seizure control could not be achieved with phenobarbital
and midazolam alone. … , and drug-drug interaction in asphyxiated neonates undergoing …

… to the alteration of the pharmacokinetics in drugs and may … such as phenobarbital and
midazolam are commonly … aspiration syndrome, neonatal asphyxia and hypoglycemia, with …

… drug-drug interactions can also be of relevance as phenobarbital is an inducer (factor 2.3
higher) of midazolam … is 22% lower in asphyxiated neonates exposed to WBH when compared …

… agent instead of phenobarbital, the dose of midazolam should be … , and drug- drug interaction
in asphyxiated neonates … the pharmacokinetic parameters of phenobarbital in asphyxiated …

… Phenytoin and phenobarbital are both effective treatments in partial (focal) and tonic-clonic …
it has shown higher efficacy in treating refractory seizures compared to midazolam [14]. …

… , respiratory depression, and drug-drug interactions [14]. SC is … with phenobarbital causes
an increase in midazolam … The pharmacokinetic properties of phenobarbital have shown to …