Hepatitis C Virus and the Host: A Mutual Endurance Leaving Indelible Scars in the Host's Immunity
… intrahepatic recruitment of HCV-specific CD8+ T cells. This suggests that intrahepatic T cell
… by successful DAA treatment induced phenotypic changes in exhausted T cells, which seem …
… by successful DAA treatment induced phenotypic changes in exhausted T cells, which seem …
Unraveling the multifaceted nature of CD8 T cell exhaustion provides the molecular basis for therapeutic T cell reconstitution in chronic hepatitis B and C
… in chronic hepatitis C a subset of virus-specific CD8 T cells … could restore exhausted
intrahepatic CXCR5+ CD8 T cells, via … with the exhaustion phenotype in HCV-specific CD8 T cells. …
intrahepatic CXCR5+ CD8 T cells, via … with the exhaustion phenotype in HCV-specific CD8 T cells. …
[PDF][PDF] Natural killer cells regulate the maturation of liver sinusoidal endothelial cells thereby promoting intrahepatic T‐cell responses in a mouse model
Y Du, H Yan, S Zou, T Khera, J Li, M Han… - Hepatology …, 2021 - Wiley Online Library
… LSEC phenotype and the ability of LSECs to activate T cells were … T cells was significantly
increased in the spleen of CXCR3−/− mice, although the number of intrahepatic CD8+ T cells …
increased in the spleen of CXCR3−/− mice, although the number of intrahepatic CD8+ T cells …
[HTML][HTML] Hepatocytes infected with hepatitis C virus change immunological features in the liver microenvironment
… phenotype [25], TGF-β has a negative influence on effector T-cell function and is known to
be involved in Treg cell and Th17 … C, and AIH livers and significant portions of intrahepatic …
be involved in Treg cell and Th17 … C, and AIH livers and significant portions of intrahepatic …
What Is the Current Status of Hepatitis B Virus Viro-Immunology?
C Boni, M Rossi, I Montali, C Tiezzi… - Clinics in Liver …, 2023 - liver.theclinics.com
… Phenotypic CD8 T cell profiling in chronic hepatitis B to predict HBV-specific CD8 T cell
susceptibility to functional … Restored function of HBV-specific T cells after long-term effective …
susceptibility to functional … Restored function of HBV-specific T cells after long-term effective …
Priming of antiviral CD8 T cells without effector function by a persistently replicating hepatitis C-like virus
AS Hartlage, CM Walker, A Kapoor - Journal of virology, 2020 - Am Soc Microbiol
… Virus-specific CD8 T cells were assessed for effector function … pi showing percentage of
intrahepatic CD8 T cells that stain … a detailed analysis of their phenotype during infection. Using …
intrahepatic CD8 T cells that stain … a detailed analysis of their phenotype during infection. Using …
Diverse facets of MDSC in different phases of chronic HBV infection: Impact on HBV‐specific T‐cell response and homing
S Pal, D Dey, BC Chakraborty, M Nandi, M Khatun… - …, 2022 - Wiley Online Library
… A diversity was noted in the functional state of MDSCs across … The intrahepatic MDSCs of
patients with CHB were also found … Our results highlighted that the phenotypic and functional …
patients with CHB were also found … Our results highlighted that the phenotypic and functional …
… programmed cell death-1 and T-cell immunoglobulin and mucin domain-containing protein 3 and plasma IL-10 levels after successful treatment of chronic hepatitis C
S Osuch, T Laskus, H Berak, K Perlejewski… - Scientific reports, 2020 - nature.com
… Successful treatment of chronic hepatitis C with DAA is associated with reversal of immune
exhaustion phenotype, but this effect is absent in patients with advanced liver fibrosis. …
exhaustion phenotype, but this effect is absent in patients with advanced liver fibrosis. …
Direct-acting antiviral treatment downregulates immune checkpoint inhibitor expression in patients with chronic hepatitis C
… T cells and increases NK cell cytotoxicity against T helper … activation of intrahepatic and
blood innate immune cells, … on the analysis of phenotype distribution and different immune …
blood innate immune cells, … on the analysis of phenotype distribution and different immune …
The hepatic microenvironment and regulatory T cells
… the hepatic tolerogenic state; however, the phenotypic stability, function and survival … T
cells, but also intrahepatic DCs can produce IL-10 to maintain hepatic tolerance [28]. Intrahepatic …
cells, but also intrahepatic DCs can produce IL-10 to maintain hepatic tolerance [28]. Intrahepatic …