Paternal diabetes programs sex-dependent placental alterations and fetal overgrowth

D Fornes, F Heinecke, CR Gatti… - Journal of …, 2022 - joe.bioscientifica.com
Triglyceride, cholesterol and free fatty acid levels were … of these maternal insults, such as
malnutrition, obesity and type 1, … Both placental lipoprotein lipase (LPL) and endothelial lipase (…

Diabetes mellitus, obesity, and the placenta

G Desoye, M Cervar-Zivkovic - Obstetrics and Gynecology …, 2020 - obgyn.theclinics.com
… store more triglycerides, but also have a greater number of … accumulated excess fat during
intrauterine growth. Furthermore, … upregulated in type 1 diabetes as a result of elevated insulin …

Sex-specific impact of maternal obesity on fetal placental macrophages and cord blood triglycerides

LL Shook, KE James, DJ Roberts, CE Powe, RH Perlis… - Placenta, 2023 - Elsevier
… digestion with microbial lipase followed by glycerol … test if maternal obesity, fetal sex, and
smoking status were significantly associated with HBC densityand placental gene expression

Revisiting preeclampsia: a metabolic disorder of the placenta

M Hu, J Li, PN Baker, C Tong - The FEBS journal, 2022 - Wiley Online Library
… FABPs support fat accumulation in placenta in the conditions of … gene expression is
significantly compromised in human … of triglyceride by means of adipose triglyceride lipase, is …

Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin

P Guadix, I Corrales, T Vilariño-García… - Frontiers in …, 2023 - frontiersin.org
… An increase in maternal circulating triglycerides (TGs) and … Maternal TGs require lipase
enzyme activity to cross the … , as the placenta and fetus cannot synthesize adequate amounts of …

… fatty acid transporter FABP1 and increased isoprostanes and neuroprostanes in the human term placenta: implications for inflammation and birth weight in maternal …

L Belcastro, CS Ferreira, MA Saraiva, DB Mucci… - Nutrients, 2021 - mdpi.com
… acids from triacylglycerol in lipoproteins is catalyzed by endothelial lipase and by lipoprotein
lipase. … in the obese group (p < 0.05) and the median BMI value indicates obesity class I. …

Effects of maternal obesity and gestational diabetes mellitus on the placenta: current knowledge and targets for therapeutic interventions

S Bedell, J Hutson, B de Vrijer… - Current vascular …, 2021 - ingentaconnect.com
… reduced in type-1 diabetic rats along with increased uterine … pregnancy in the mesometrial
triangle of type 1 diabetic rats. … and increase triglyceride accumulation in human placenta. Am …

Ex-vivo Placental Lipid Metabolism of Normal Weight, Overweight and Diabetic Women: A Preliminary Study

J Aminu, C Witharana… - Journal of …, 2021 - journal.hibiscuspublisher.com
Triglyceride levels of placental tissue, maternal, and cord … /obese rat placenta had higher
lipid accumulation in all … when compared to mothers with type 1 diabetes, this might be …

Decreased fatty acid oxidation gene expression in pre-Eclampsia according to the onset and presence of intrauterine growth restriction

A Abascal-Saiz, E Fuente-Luelmo, M Haro… - Nutrients, 2023 - mdpi.com
… in lipoprotein lipase (LPL), which hydrolyzes triglycerides into … the FFA and triglyceride
placental and maternal serum levels… FAO enzyme mRNA expression at the placenta also occurs …

[引用][C] Placental expression of Fatty Acid Desaturases 1, 2 and 3 in selected pregnancy pathologies

…, U Mazurek, N Zmarzly, I Ulman-Włodarz… - Acta Biochimica …, 2023 - ojs.ptbioch.edu.pl
… non-esterified FAs and triglycerides increases in the mother’s … with an insulin-dependent
decrease in lipoprotein lipase activi… accumulated fat is transferred to the foetus via the placenta. …