[HTML][HTML] Thin-layer chromatography (TLC) in the screening of botanicals–its versatile potential and selected applications
T Kowalska, M Sajewicz - Molecules, 2022 - mdpi.com
… of the Lauraceae family show variations and similarities in … plates with the plant extracts
developed and fractionated on … (AChE) and butyrylcholinesterase (BuChE) currently form the …
developed and fractionated on … (AChE) and butyrylcholinesterase (BuChE) currently form the …
Rational redesign of enzyme via the combination of quantum mechanics/molecular mechanics, molecular dynamics, and structural biology study
HY Lin, X Chen, J Dong, JF Yang, H Xiao… - Journal of the …, 2021 - ACS Publications
… variant Q307A and checked its product profile. It revealed that Q307A mutation slightly
increased … Thus, we developed a rational redesign strategy of manipulating this amide-rich zone, …
increased … Thus, we developed a rational redesign strategy of manipulating this amide-rich zone, …
Esterases and Their Industrial Applications
… A corresponding cataloging scheme has been developed to … Plants, animals, and
microorganisms have been recognized … C and exhibit several molecular variations in comparison …
microorganisms have been recognized … C and exhibit several molecular variations in comparison …
[HTML][HTML] Hinge-shift mechanism as a protein design principle for the evolution of β-lactamases from substrate promiscuity to specificity
T Modi, VA Risso, S Martinez-Rodriguez… - Nature …, 2021 - nature.com
… by inferring the sequence variations between the ancestral and the … developed a design
principle to evolve the antibiotic activity … design principles to enhance or fine-tune the activity of …
principle to evolve the antibiotic activity … design principles to enhance or fine-tune the activity of …
[HTML][HTML] Medicarpin and Homopterocarpin Isolated from Canavalia lineata as Potent and Competitive Reversible Inhibitors of Human Monoamine Oxidase-B
JM Oh, HJ Jang, MG Kang, SK Mun, D Park, SJ Hong… - Molecules, 2022 - mdpi.com
… butyrylcholinesterase (BChE) is a serine hydrolase that rapidly affects the hydrolysis of the
neurotransmitter ACh. The main catalytic activity … Canavalia lineata is a tendril perennial plant …
neurotransmitter ACh. The main catalytic activity … Canavalia lineata is a tendril perennial plant …
A Computational Method to Predict Effects of Residue Mutations on the Catalytic Efficiency of Hydrolases. Catalysts 2021, 11, 286
Y Li, K Song, J Zhang, S Lu - 2021 - search.proquest.com
… variants with enhanced properties (thermal, pH, solvent, and … design of epoxide hydrolases
was operated to enhance their … Two amino acid substitutions of butyrylcholinesterase (BChE) …
was operated to enhance their … Two amino acid substitutions of butyrylcholinesterase (BChE) …
Design of novel cyanovirin-N variants by modulation of binding dynamics through distal mutations
… , and predict binding energies of its variants through Adaptive BP-Dock. Computational and
experimental analyses reveal that binding enhancing mutants identified by ICDC impact the …
experimental analyses reveal that binding enhancing mutants identified by ICDC impact the …
Ashwagandha in brain disorders: A review of recent developments
… A large number of medicines are derived from plant-based … for drug design with upgraded
and better pharmacological … Dopaminergic activity of a drug can enhance memory, and …
and better pharmacological … Dopaminergic activity of a drug can enhance memory, and …
[HTML][HTML] Targeting cannabinoid receptors: current status and prospects of natural products
D An, S Peigneur, LA Hendrickx, J Tytgat - International journal of …, 2020 - mdpi.com
… In the meantime, some efforts have been made to discover … from natural sources, other than
the cannabis plant. Examples … The inverse agonistic activity of Pep19 is greatly enhanced …
the cannabis plant. Examples … The inverse agonistic activity of Pep19 is greatly enhanced …