… (knees, elbows, hips, and shoulders) was assessable by micro-CT scan but not by clinical
evaluation, we hypothesized that vWF-deficient mice had more septic arthritis in deeper joints …

… perform the joint injection procedure due to the small size of the mouse knees and the …
than pathogenic. In experiments involving human plasminogen transgenic mice inoculated with …

… how plasminogen contributes to disease pathogenesis. … In addition, in a mouse model of
systemic arthritis in which joint … joints of plasminogen-deficient mice but not in the paw joints. …

… an important determinant of inflammatory arthritis through its … had fewer arthritic joints
compared with the control mice 30 . … the fibrin clot breakdown by plasmin. As traditional markers of …

… Plasminogen is 722 a joint-specific positive or negative determinant of arthritis
pathogenesis in mice. Arthritis 723 Rheumatol. 2014;66(6):1504-16. 724 …

… Arthritis (RA) is the most common chronic inflammatory joint … The structural integrity of formed
blood clots is a major determinant … We consider RA pathogenesis within a systems biology …

… We consider RA pathogenesis within a systems biology approach, … [120] Plasmin is a serine
proteinase that cleaves peptide bonds … keratoconus (SKC) mouse model produces rapid RA …

… clots via activation of plasminogen to plasmin, has been shown … mice exhibited less arthritis
compared to wild-type mice in … of gut microbiota in osteoarthritis pathogenesis. Interestingly, …

… In addition, they also suggested the joint inflammation mechanism … In our study, inhibiting
plasmin production might inhibit platelet … In summary, we investigated the mechanism of RA …

… joints has been found in some patients with joint diseases including hemophilic arthropathy,
hemochromatosis arthropathy, and osteoarthritis (… iron overloaded mice by intraperitoneal …