Antibody to Plasmodium falciparum Variant Surface Antigens, var Gene Transcription, and ABO Blood Group in Children With Severe or Uncomplicated Malaria

P Barua, MF Duffy, L Manning, M Laman… - The Journal of …, 2023 - academic.oup.com
… The present study used P falciparum isolates collected from children in Papua New Guinea
(… causing isolate, when available. Recognition by positive controls varied within and between

Evolutionary analyses of the major variant surface antigen-encoding genes reveal population structure of Plasmodium falciparum within and between continents

…, S Zakeri, T Pumpaibool, P Harnyuttanakorn… - PLoS …, 2021 - journals.plos.org
… of the reduced number of isolates leading to a weaker signal … and thus changes in distances
between clusters cannot be … falciparum field isolates from 23 locations in 10 countries, we …

Selective expression of variant surface antigens enables Plasmodium falciparum to evade immune clearance in vivo

…, R Hoo, Q Chen, JC Niles, J Chen, P Preiser - Nature …, 2022 - nature.com
… compared to parasites directly isolated from patients 19,20 … characterized the changes that
occur when in vitro cultured P. … evasion and may lead to improved intervention strategies. …

The exception that proves the rule: Virulence gene expression at the onset of Plasmodium falciparum blood stage infections

JS Wichers-Misterek, R Krumkamp, J Held… - Plos …, 2023 - journals.plos.org
… with the Plasmodium falciparum (Pf) NF54 isolate, which is of … Malaria caused by Plasmodium
falciparum (Pf) remains one … linked to the variant surface antigen Pf erythrocyte membrane …

Detection of naturally acquired, strain-transcending antibodies against rosetting Plasmodium falciparum strains in humans

FE McLean, Y Azasi, C Sutherland, E Toboh… - Infection and …, 2024 - Am Soc Microbiol
… One subset of surface antigens associated with severe … Erythrocyte Membrane Protein
one (PfEMP1) variants, causefalciparum isolates that share antigenic determinants with the …

Microarray analyses reveal strain-specific antibody responses to Plasmodium falciparum apical membrane antigen 1 variants following natural infection and …

JA Bailey, AA Berry, MA Travassos, A Ouattara… - Scientific reports, 2020 - nature.com
… -mer AMA1 peptides derived from our field isolates and publicly … could lead to a better
serological correlate of protection fromvary in their risk of clinical malaria episodes, ranging from

Characterization of a novel Plasmodium falciparum merozoite surface antigen and potential vaccine target

K Niaré, T Chege, M Rosenkranz, K Mwai… - Frontiers in …, 2023 - frontiersin.org
… is caused by the most deadly species, Plasmodium falciparum, … population structure between
parasite isolates from West … did not vary by country as reported previously for other antigen

Genetic diversity of Plasmodium falciparum and distribution of antimalarial drug resistance mutations in symptomatic and asymptomatic infections

EM Sarah-Matio, E Guillochon… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
… the proportion of the wild type varied from 1.2 to 97.4% in these … We showed that polyclonal
infections lead to lower parasite … , and our results from natural parasite isolates suggest that …

Genetic diversity and expression profile of Plasmodium falciparum Pf34 gene supports its immunogenicity

S Krishna, S Bhandari, AK Vishwakarma… - Current Research in …, 2021 - Elsevier
… Pf34 orthologues sequences of various Plasmodium species. … 92%) of Plasmodium falciparum
isolates in available database … seven haplotypes leading to six amino acid variants of Pf34 …

Expression patterns of Plasmodium falciparum clonally variant genes at the onset of a blood infection in malaria-naive humans

AK Pickford, L Michel-Todó, F Dupuy, A Mayor… - Mbio, 2021 - Am Soc Microbiol
… disease malaria, which causes over 200 million clinical … genetic diversity among isolates,
which mainly affects CVGs. The … Since we observed changes in the expression of clag3 genes…