[HTML][HTML] γδ T cells kill Plasmodium falciparum in a granzyme-and granulysin-dependent mechanism during the late blood stage

…, B Scolari, N Lannes, S Mbagwu, B Fellay… - The Journal of …, 2020 - journals.aai.org
… were efficiently destroyed by granzyme B, suggesting proteolytic … falciparuminfected RBCs,
we incubated the activated … We also demonstrate that the killer cells release GzmB, which is …

γδ T cells suppress Plasmodium falciparum blood-stage infection by direct killing and phagocytosis

C Junqueira, RB Polidoro, G Castro, S Absalon… - Nature …, 2021 - nature.com
… are expanded in Plasmodium falciparuminfected patients. … GNLY), perforin (PFN) and
granzyme B (GzmB) in 8 HD and 8 … trigger T and NK cells to degranulate and kill target cells via

NK cell-induced damage to P.falciparum-infected erythrocytes requires ligand-specific recognition and releases parasitophorous vacuoles that are phagocytosed by …

P Sekar, S Rajagopalan, E Shabani, U Kanjee… - PLoS …, 2023 - journals.plos.org
… shown that NK cells lyse Plasmodium falciparum-infectedGranzyme B substrate was then
added to the cells and … CD2 expression is upregulated in adaptive NK cells [36]. It is therefore …

[HTML][HTML] Plasmodium falciparum malaria exposure and carriage associate with reduced γδ T-cells and NK cell responses to infected red blood cells in vitro

B Kouriba, M Daou, C Arama, N Ouédraogo, K Niaré… - 2023 - europepmc.org
falciparum infected red blood cells (PfRBC). … Such PD-1 expressing NK cells, when induced
in vitro, associates … NK cell Granzyme B content on the other hand showed a trend for higher …

Antibodies targeting merozoites induce natural killer cell degranulation and interferon gamma secretion and are associated with immunity against malaria

DO Odera, J Tuju, K Mwai, IN Nkumama, K Fürle… - medRxiv, 2021 - medrxiv.org
… release of cytotoxic molecules like granzyme B, as well as the … falciparum infected erythrocytes
via NK cells leading to their … -merozoite antibodies induce NK cell degranulation and IFNγ …

Antibody-Mediated Natural Killer Cell Function against Plasmodium falciparum

DO Obonyo - 2023 - oro.open.ac.uk
induced comparable ab-NK responses. Conclusions: These findings identify ab-NK cell
, thank you for your assistance in expressing proteins and generating the microarray dataset. I …

[HTML][HTML] Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro

L Ramatsui, TH Dongola, T Zininga, G Multhoff… - Cell Stress and …, 2023 - Elsevier
… to recruit NK cells to the immunological synapse via the … Plasmodium falciparum-infected
red blood cells (RBCs) habour both … GrB release by NK cells via the expression of host Hsp70 (…

Anti-merozoite antibodies induce natural killer cell effector function and are associated with immunity against malaria

…, N Kibinge, S Kinyanjui, P Bejon, B Lowe… - Science Translational …, 2023 - science.org
… release of cytotoxic molecules like granzyme B as well as the … falciparuminfected erythrocytes
via NK cells, leading to their … -merozoite antibodies induce NK cell degranulation and IFN-…

PD-1 expression on NK cells in malaria-exposed individuals is associated with diminished natural cytotoxicity and enhanced antibody-dependent cellular cytotoxicity

…, K Abdi, J Skinner, S Li, G Arora, B Traore… - Infection and …, 2020 - Am Soc Microbiol
… Earlier studies described direct lysis of P. falciparum-infected erythrocytes by NK cells in
the … of inhibitory receptors trigger NK cells, we found that PD-1-expressing NK cells showed …

A Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin

…, M Lavergne, P Casanova, B Nydegger… - Frontiers in …, 2021 - frontiersin.org
… of granzyme B (GzmB) predominantly in early stages of P. … Cytotoxic granules were purified
from the human NK cell line … Disclaimer: All claims expressed in this article are solely those of …