Clot-Targeted Enzyme-Responsive Nanoparticles for Thrombolytic Therapy

M Sun - 2022 - search.proquest.com
Platelet microparticle-inspired nanoparticle … has established the promise of nanomedicine
for safer site-targeted … quiescent and active platelets as well as fibrinolytic ability in microfluidic …

Thrombolytic agents: nanocarriers in targeted release

M Shen, Y Wang, F Hu, L Lv, K Chen, G Xing - Molecules, 2021 - mdpi.com
… , which targeted the activation of platelets for the local release of urokinase, resulting in targeted
thrombolysis, … Liposomes can also target P-selectin on the surface of activated platelets. …

Nano-medicine for thrombosis: a precise diagnosis and treatment strategy

M Su, Q Dai, C Chen, Y Zeng, C Chu, G Liu - Nano-Micro Letters, 2020 - Springer
… The cyclic Arg-Gly-Asp (cRGD) peptide was reported to target the activated platelets due
to the surface-… These results confirmed the targeted thrombolysis capability of multi-functional …

Advancement and Applications of Platelet-inspired Nanoparticles: A Paradigm for Cancer Targeting

D Ghose, S Swain, CN Patra, BR Jena… - Current …, 2023 - ingentaconnect.com
Platelet-inspired nanoparticles or medicines are the most recent nanotechnology-based drug
targeting … vivacious principle supportive delivery of fibrinolytic agents. These can take place …

[HTML][HTML] Thrombus-targeting polymeric nanocarriers and their biomedical applications in thrombolytic therapy

Q Guan, H Dou - Frontiers in physiology, 2021 - frontiersin.org
… by the development of nanotechnology in recent years may … mechanism of thrombosis and
thrombolysis, we outline the … the platelet membrane is concerned, the targeting mechanism …

Accelerating thrombolysis using a precision and clot-penetrating drug delivery strategy by nanoparticle-shelled microbubbles

S Wang, X Guo, W Xiu, Y Liu, L Ren, H Xiao, F Yang… - Science …, 2020 - science.org
… strategies using RGD (Arg-Gly-Asp) motif (binding to active platelet integrin GPIIb/IIIa) or
anti… steps of nanomedicine for thrombolysis, ie, activity maintenance in circulation, targeting to …

Advances in Nano-Functional Materials in Targeted Thrombolytic Drug Delivery

T Ren, Y Mi, J Wei, X Han, X Zhang, Q Zhu, T Yue… - Molecules, 2024 - mdpi.com
targeting ability of this particle combined with photothermal thrombolysis has the potential
to achieve nanomedical … Nanoparticles used for thrombolysis itself can also cause platelet

Targeted nano-delivery strategies for facilitating thrombolysis treatment in ischemic stroke

H Ma, Z Jiang, J Xu, J Liu, ZN Guo - Drug Delivery, 2021 - Taylor & Francis
… of various nanotechnology-based strategies for targeted … -targeted thrombolysis was
shown by the work of Pawlowski and colleagues, who developed platelet microparticle-inspired

[HTML][HTML] Beyond the thrombus: Platelet‐inspired nanomedicine approaches in inflammation, immune response, and cancer

C Desai, M Koupenova, KR Machlus… - Journal of Thrombosis and …, 2022 - Elsevier
… In our research focused on the development of platelet‐… of platelet‐inspired nanomedicine
strategies for targeted … research has focused on the design of platelet‐derived and platelet‐…

[HTML][HTML] Direct delivery of plasmin using clot-anchoring thrombin-responsive nanoparticles for targeted fibrinolytic therapy

M Sun, MHH Pontius, S Yang, T Pendekanti… - Journal of Thrombosis …, 2023 - Elsevier
… a nanomedicine approach can enable direct delivery of plasmin (instead of tPA) for rapid …
platelets and deliver drugs like Streptokinase (for fibrinolysis) or tranexamic acid (for …