… fungal antibiotic plectasin is a eukaryotic host defence peptide that blocks bacterial cell wall
… to show oligomerization for different lipid II binders including the αβ-defensin copsin 31 and …

… membrane bacterial targets such as Lipid II, outer membrane … Py4 and Lipid II based on that
of plectasin and Lipid II (Figure 1C,… of plectasin with Lipid II [24] also exists in the Py4-Lipid II …

… The bacterial cell wall precursor lipid II is another target of … (B) NaD1 kills fungi by a three-step
mechanism involving cell wall … Once such example is a defensin variant Plectasin, also …

… Lipid II is the site of action of many drugs targeting the cell … Plectasin and its derivative
NZ2114 are non-lytic membrane AMP, which could bind to lipid II to block bacterial cell wall …

… to lipid II, suggesting this cell wall precursor as the target of … determined that plectasin binds
to lipid I and lipid II with a 1 [thin … defensins, lucifensin and gallicin, also bind to lipid II. Shortly …

… dysgalactiae cell membrane was first identified in this study. The PI-stained percentages of
S… important targets of P2. Plectasin with a similar sequence to P2 interacts with lipid II at the …

… binding of defensins to lipid II, a bacterial cell wall precursor, and … For plectasin, the
pyrophosphate moiety of lipid II is primarily … Target-induced conformational changes have also …

… (LAB), its role as the target for bacteriocins, bacteriophages … The CW precursor lipid II plays
key roles in the physiology of … , vancomycin and the fungal defensin plectasin (M ünch and …

… Plectasin is a cysteine-stabilized αβ defensin and a derivative of … One such target is lipid
II (LII), as it is the major building block for the bacterial cell wall and often referred to as its ‘…

… cell membrane-targeting daptomycin and cell wall-targeting … the druggability of the fungal
defensin plectasin; moreover, Ple… the plectasin-Lipid II interaction, signifying a conserved lipid II-…