… polymorphism might alter the function of the P-gp transporter within the BBB. However, it is
also possible that the polymorphism is … actually influences the efficacy of the P-gp transporter. …

… development to assess DDI liability, its clinical relevance, and to determine appropriate DDI
management strategies. P-glycoprotein (P-gp) … the most frequent polymorphism in the gene …

… (C3435T) polymorphism may play a role in inducing drug resistance by altering the expression
level of the MDR1 gene. To summarize, we suggest that the expression of MDR1 in OC is …

… This review details the discovery, the recently proposed structure and the regulatory
functions of Pglycoprotein, as well as the crucial role it plays in health and disease. …

… current understanding of the role of P-gp in cancer cells and immune cells and finally attempt
to highlight some caveats in the current … in the development of P-gp inhibitors toward anti-…

… nucleotide polymorphisms in the MDR1 … polymorphism on P-glycoprotein at the blood-brain
barrier has remained unclear. In the present study, we developed a novel P-glycoprotein …

… function using various inducers, inhibitors, or genetic polymorphisms is a common strategy
[… Recent advances in understanding the structure and mechanism of P-gp and the related …

… Polymorphisms in ABCF1 gene have been implicated with a relationship with autoimmune
… , such as previously reports described in clinical relevance in each gene, however, some …

… Concluding, we may state that SSRIs and SNRIs are currently the most clinically relevant
antidepressant drugs for the treatment of depressive disorders and, because of that, the …

… None of the four models presented a significant association of either polymorphism with the
risk of infertility in men (p >.05). The present study indicates that MDR1 gene polymorphisms …