… Antigen binding to the B cell antigen receptor (BCR) initiates … B cell, while interacting with
the immobilized antigens on a … to membrane microdomains and calcium flux, but are equally …

… In this process, B cells capture diverse antigens in various … a role for lipid microdomains in
BCR signaling, one avenue for … 4 ml of 0.75% PFA in stabilization buffer (70 mM KCl, 5 mM …

… ERK induced activation of WAVE2 may stabilize BCR … that selforganize into lipid rafts or
microdomains [56]. The other … BCRs and other membrane proteins on the surface of the B cell …

… or for engagement with inhibitory cell surface receptors to dampen BCR signaling. To make
… We found that dimeric and higher valent antigens readily internalize into the B cell at low nM …

… C-terminal tail tyrosine results in stabilization of a closed, inactive … in B cells when polyvalent
antigens or cross-linked antibodies … into cholesterol-enriched microdomains on the plasma …

… Inhibition of actin remodeling using the f-actin stabilizing drug … complex and subsequently
present antigens to T cells. An … with lipid raft microdomains than antigen stimulated BCRs, and …

… B cell receptors (BCRs) to induce receptor clustering within membrane microdomains, activating
cells … displaying ∼4–7 antigens on hyaluronic acid provided optimal B cell inhibition, (26…

… a B-cell-intrinsic inhibition on BCR signaling by regulating B-cell membrane contraction and
surface … receptor (BCR), which senses foreign antigens (Ag). Ag binding of the BCR initiates …

… receptor type 2), a B cell specific receptor that binds antigens … them to organize membrane
microdomains of a particular … have a key role in stabilization of the coneshaped architecture of …

… Finally, chapter 4 utilized PEG SAgAs displaying a B cell … (BCR) is involved in the recognition
of antigens and B cell … lead to steric stabilization, where binding to receptors is impaired.…