… Although the population PK model developed in this study could be used to predict dosing
… in critically ill patients identified a nonlinear clearance component with an estimated K m of …

… the mode of infusion having seemingly little impact on their performance, we aimed to use
these models for initial dosing recommendations of piperacillin for ICU patients. As the models …

… Objectives: This study aimed to develop a piperacillin population PK model for critically ill …
of piperacillin treatment and assayed by HPLC-UV. Population pharmacokinetic modelling …

… We aimed to develop a piperacillin population pharmacokinetic (PK) … therapy (CRRT) and
to optimize dosing regimens. The … Piperacillin PK was investigated using a nonlinear mixed-…

… In this work, a novel approach to constructing a set of fully artificial population pharmacokinetic
quasi-models (QM) is put … A nonlinear relationship existed between the concentrations of …

… Continuous infusion (CI) piperacillin/tazobactam is frequently … to conduct a population
pharmacokinetic analysis of CI piperacillin/… Non-linear mixed-effects modelling was performed with …

… The following search terms were used: piperacillin AND (population pharmacokinetic OR
NONMEM OR NLME OR nonlinear mixed effect OR non linear mixed effect) AND (intensive …

… was to use a population PK modeling approach to quantify how the systemic CL of
piperacillin/tazobactam changes with … A population PK analysis was conducted using nonlinear …

… and integrated by use of the non-linear mixed-effects modelling approach, which takes all
… may have influenced the piperacillin tissue penetration; however, we consider this influence …

… piperacillin population pharmacokinetic models for their application in a model-informed
precision dosing … The simulations were developed using the non-linear mixed-effects modeling …