… the ligand-binding domain of the glucocorticoid receptor (GR), … The gene-specific impact of
GR variants has been described … Our functional studies support the critical role of H3 and the …

… [9,10,11,12]; the DNA-binding domain (DBD), corresponding to amino acids 420–480 and
containing two zinc finger motifs enabling the receptor to bind to specific DNA sequences [the …

… a role for single nucleotide polymorphisms (SNPs) of the … common haplotypes contained the
Tth111I-variant. Although we found no … The gene location of the studied SNPs, their specific …

… to GR-mediated negative feedback, highlighting the potential role of the dysregulation of this
… , selecting the variants located in the NR3C1 gene after filtering with the VEP (Variant Effect …

… glucocorticoid receptor (GR) number [2,3]. However, lower levels of cortisol have mainly been
found in specific populations and at specific … of the GRβ splice variant is low for cells other …

… between the genetic and epigenetic variants of the NR3C1 gene in … The role of the NR3C1
gene in SLE has been studied. Yang-… and methylation at specific regions of the GR gene is …

… outcomes is the NR3C1 gene, in particular, its variants. … in differences in predisposition to
certain immune-mediated … patients, what might suggest the possible role of minor C allele in MN…

… the glucocorticoid receptor (GR, encoded by NR3C1 gene in … 7.9% of NR3C1 variants (44)
with one new GR variant, N454S… NR3C1 genetic screening should be performed in selected …

… Many studies point out to an influential role of the interaction between immune and …
SNPs in the GR receptor gene, and its potential relationship with a certain chronic condition. …

… El-Hage and colleagues [10] found that genetic variants in NR3C1 … to explore the role of the
glucocorticoid cortisol on this path. … For NR3C1 and NR3C2 we selected the transcript whose …