Multiple roles for AU-rich RNA binding proteins in the development of haematologic malignancies and their resistance to chemotherapy

P Podszywalow-Bartnicka, KM Neugebauer - RNA biology, 2024 - Taylor & Francis
Post-transcriptional regulation by RNA binding proteins can … AUF1 recognizes U-rich and
GU-rich motifs to either upregulate … Apart from mutations, disturbed cytokine signalling, and …

[HTML][HTML] Shaping the innate immune response through post-transcriptional regulation of gene expression mediated by RNA-binding proteins

A Guillemin, A Kumar, M Wencker, EP Ricci - Frontiers in immunology, 2022 - frontiersin.org
… and TLR8 rely on leucine-rich repeats to detect GU-rich ssRNA species (70) but also by-products …
Historically, AU-rich elements were discovered as cis-acting elements responsible for …

Tristetraprolin-RNA interaction map reveals a novel TTP-RelB regulatory network for innate immunity gene expression

Y Tu, X Wu, F Yu, J Dang, Y Wei, H Yu, W Liao… - Molecular …, 2020 - Elsevier
… and its binding of AU-rich elements for degradation of … Our observation of GU-rich motif
in TTP peaks suggest that … broadening the post-transcriptional gene regulation operated …

[HTML][HTML] RNA recognition and immunity—innate immune sensing and its posttranscriptional regulation mechanisms

T Uehata, O Takeuchi - Cells, 2020 - mdpi.com
… This mechanism partially explains the reason why GU-rich sequences are important for the
… of the AUUUA pentamer and forms ARE clusters in an AU-rich context [94]. In the genome, …

Pro-and Anti-Tumorigenic Activities of the RNA-binding Protein AUF1

NC Lee, GM Wilson - RNA-based Mechanisms in Cancer, 2024 - World Scientific
control of mRNAs containing AU-rich elements (AREs), … extensive binding to U- and GU-rich
motifs in addition to canonical … can also be regulated by post-transcriptional mechanisms. …

[PDF][PDF] Translational Molecular Medicine and Surgery

CPG Caramori - 2022 - iris.unime.it
… demonstrated the loss of AUrich element factor 1 (AUF-1) in … in COPD by altering post-transcriptional
control of epithelial gene … -rich sequences, defined as GU-rich element (GRE). The …

[HTML][HTML] Aberrant post-transcriptional regulation of protein expression in the development of chronic obstructive pulmonary disease

N Aloufi, A Alluli, DH Eidelman, CJ Baglole - International Journal of …, 2021 - mdpi.com
… Activators of mRNA decay recognize the constitutive decay AU- and GU-rich elements of …
, HuR also targets mRNAs which have U- or AU-rich elements (AREs) in the 3’-untranslated …

The 3′ Untranslated Regions of Ebola Virus mRNAs Contain AU-Rich Elements Involved in Posttranscriptional Stabilization and Decay

EV Nelson, SJ Ross, J Olejnik, AJ Hume… - The Journal of …, 2023 - academic.oup.com
Post-transcriptional regulation of cytokine signaling by AU-rich and GU-rich elements. J …
RNA binding proteins: at the crossroads of posttranscriptional regulation and genome integrity. …

Control of RNA stability in immunity

S Akira, K Maeda - Annual review of immunology, 2021 - annualreviews.org
… The 3′ UTRs of many cytokines, chemokines, and protooncogenes contain adenylate-uridylate-rich
elements (AU-rich elements; AREs), characterized by AUUUA nucleotide repeats, …

[HTML][HTML] Dynamic post-transcriptional events governing CD8+ T cell homeostasis and effector function

F Salerno, M Turner, MC Wolkers - Trends in immunology, 2020 - cell.com
… of cytokine production in CD8 + T cells. We discuss the dynamic features of post-transcriptional
control … between cell signaling and RNA-binding proteins. Elucidating gene-specific …