… The 3′ UTRs of many cytokines, chemokines, and protooncogenes contain adenylate-uridylate-rich
elements (AU-rich elements; AREs), characterized by AUUUA nucleotide repeats, …

… factor (CPSF), while the GU-rich region is the binding site of … binding domains and binds the
AU-rich elements (ARE) in various … biogenesis and post-transcriptional regulation by siRNAs …

… Although this book primarily deals with the role of post-transcriptional regulation of gene
expression in diseases, this chapter is aimed toward giving a general background on gene …

… The link between MK2 and target mRNAs is the AU-rich elements binding protein tristetraprolin
(TTP; also called ZFP36). Not only the activity of p38 and its downstream kinase MK2 is …

… role for pattern recognition receptor signaling in controlling splicing factor phosphorylation
and establish pre-mRNA splicing as a critical regulatory node in defining innate immune …

… Post-transcriptional regulation plays a key role in the function of TH lymphocytes by … those
encoding for cytokines and other immune-relevant genes. This level of regulation is tightly …

… away from AGO by the AU-rich binding protein HuR (derived from … Upon transfer, they can
serve as post-transcriptional … These receptors bind GU-rich single-stranded RNAs of both viral …

… Several (molecular) layers of regulation have been described that keep excessive T cell …
cell activation, three signals (TCR, co-stimulation and cytokine/chemokine signals) are required …

… This post-transcriptional regulation is a crucial aspect in the … HOTAIR, HuR binds to AU-rich
sequences that do not conform … bind to non-canonical U-rich and GU-rich sites [61,91]. Upon …

… an adenylate-uridylate-rich element (AU-rich element; ARE) in the … AU-rich sequences
shows also the ARID domain of Arid5a (26). The RRM domain of Auf1 recognizes U- and GU-rich …