Poly (A) tale: From A to A; RNA polyadenylation in prokaryotes and eukaryotes

A Mofayezi, M Jadaliha, F Zangeneh… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
… metazoans is that it provides them with additional post-transcriptional regulatory options,
paving the way for robust regulation of replication-dependent histone gene expression during …

When does hepatitis B virus meet long-stranded noncoding RNAs?

B Lei, H Song, F Xu, Q Wei, F Wang, G Tan… - Frontiers in …, 2022 - frontiersin.org
… basic elements of such pathways and characterizes the various recent targets of lncRNAs,
which not only complement the regulatory … TLR7 recognizes (in pDC) GU-rich sequences (eg, …

The mRNA stability factor Khd4 defines a specific mRNA regulon for membrane trafficking in the pathogen Ustilago maydis

S Sankaranarayanan, C Haag… - Proceedings of the …, 2023 - National Acad Sciences
… However, similar functions are known from the mammalian RBPs TTP and CELF1, which
cause rapid mRNA turnover by binding to the AU-rich and GU-rich mRNA decay elements in …

14 In Vitro RNA Transcription

P Singh, T Smith, P Arbuthnot… - Handbook of Molecular …, 2024 - books.google.com
… and is involved in the posttranscriptional regulation of gene … The various AU-rich regions
promote mRNA decay and are … 72 GU-rich sequences are susceptible to TLR recognition. 72 …

Understanding MCL1: from cellular function and regulation to pharmacological inhibition

M Sancho, D Leiva, E Lucendo, M Orzáez - The FEBS Journal, 2022 - Wiley Online Library
Post-transcriptional control of MCL1 occurs at two levels—… Several cis-acting elements have
been identified in the 3′ … -rich, AU-rich, and GU-rich elements) that regulate mRNA stability …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
… RNA binding proteins (RBPs) are known to regulate gene expression by dictating at post-transcriptional
level the fate of nascent transcripts. Their activity ranges from directing primary …

Circular RNA: a new expectation for cardiovascular diseases

Q Xie, Y Ma, Z Ren, T Gu, Z Jiang - Journal of Cellular …, 2024 - Wiley Online Library
… When pre-mRNA has a 7-nt GU-rich sequence near the 5' … Recent bioinformatics analysis
identified IRES-like AU-rich … in the transcriptional and post-transcriptional regulation of parental …

Structure-aware machine learning identifies microRNAs operating as Toll-like receptor 7/8 ligands

M Raden, T Wallach, M Miladi, Y Zhai, C Krüger… - RNA biology, 2021 - Taylor & Francis
signals for membrane receptors, a recently discovered function that is independent of the
miRNAs’ conventional role in post-transcriptional gene regulation… down GU-rich and AU-rich nt …

Therapeutic mRNA engineering from head to tail

L Jia, SB Qian - Accounts of Chemical Research, 2021 - ACS Publications
… This post-transcriptional approach is referred to as the enzymatic … cis-regulatory element is
the adenylate uridylate (AU-rich) … other cis-elements such as GU-rich elements (GRE), CU-rich …

Mapping Regulatory Elements within 5' and 3' UTRs of SIGLEC15 with a Use of Reporter System

L Wang, R Li, X Lai, X Zhang, H Chen, W Zhao - Molecular Biology, 2022 - Springer
AU-rich elements (AREs) are a class of well-characterized cis… cis-regulatory elements in 3'
UTR include GU-rich elements, … UTR mediated post-transcriptional regulation through mRNA …