… Antisense oligonucleotides (ASOs) and siRNAs are the most important tools in RNA … These
oligonucleotides have advantages in terms of potency, toxicity, delivery efficiency and target …

… affinity to complementary oligonucleotide sequences and … utilised to develop stable
antisense oligonucleotides (AO), … nucleotides-modified antisense oligonucleotides to modulate …

… and its degradation into nontoxic metabolits by natural cellular … , and these derivatives may
have strong antisense activity [61,… antisense oligonucleotide (ASO) drugs. The MOE modified …

… The first therapeutic nucleic acid, a DNA oligonucleotide, … based oligonucleotides are
specific, stable and non-toxic when … for a more potent inhibition of HIV target transcripts [63]. …

… These changes assist in the development of efficient and potent … at different locations in
the nucleic acid. Modifications at the … Locked nuclei acid is a conformationally constrained …

… Despite the choice of potent, nontoxic ASOs for this study, reduction of a few unintended …
Antisense oligonucleotides containing locked nucleic acid improve potency but cause …

… it is uncharged and is essentially non-toxic, as demonstrated in … that while making it more
potent than ASOs also makes its … the ribose sugar characterize locked nucleic acids (LNA) and …

… On the other hand, PNA(C9)F per se did not exhibit strong … , we employed artificial nucleic
acids to generate toehold-… through the use of artificial nucleic acids 66 . Furthermore, our …

… Some aggregates can form with both nontoxic and toxic PS-… , including TCP1 complex and
heat shock proteins [28,31,33–35]. Interactions with proteins can influence PS-ASO potency …

… 23 Antisense oligonucleotides (ASO) interact with precursor … It is readily taken up by cells
and 261 degrades into non-toxic … cells containing miR-18a mimic 928 exhibited a strong …