… In addition, they are inhibit CDK5 enzyme using roscovitine as a … Molecular modelling and
docking study … Å, the previous theoretical results obtained from molecular docking proved the …

… SF-539 cell line were obtained with the best results, using Roscovitine as a positive control.
… , but also inhibits CDK5, that is involved in cell migration. This dual effect make Roscovitine a …

… of the CDK5 in complex with inhibitor R-Roscovitine. It is a bi-… the most potent inhibitor of the
CDK5/p25 complex with IC 50 … peptide inhibitor of CDK5 composed of 126 residues derived …

… All of them showed potent inhibition against CDK5/P25 and … of roscovitine stimulated the
discovery of other CDK inhibitors, … as candidates for the molecular modeling study to understand …

… Molecular modeling of 25–106 as compared to another Cdk5 inhibitor, roscovitine, revealed
that 25–… Any product that may be evaluated in this article, or claim that may be made by its …

… Besides, the small molecule roscovitine (seliciclib) inhibited CDKs 2 and 5 with suspending
… of the HI 5, a potential competitive inhibitor of the CDK2. The obtained results have valuable …

… Roscovitine, aloisine, and indirubin, the inhibitors disclosed in this study, … as molecular
probes to learn more about CDK5's function in neurodegenerative diseases therapy. We obtained …

… been made in identifying potent, targeted, and efficient inhibitors … as strong inhibitors by
combining pharmacophore groups of … code 5L2W) and CDK5 and roscovitine (PDB code 1UNL) …

… The pan-selective purine CDK inhibitor roscovitine, which … modification, we employed
molecular modeling. We applied the … In contrast, the most potent inhibitors of the series (IC50 = 2−…

… the molecular interactions of two drug candidates. AZD4573 is a potent inhibitor of CDK9[13]
inducing fast apoptosis across different hematological cancer model patient-derived …