[HTML][HTML] Expanding Role of Interleukin-1 Family Cytokines in Acute Ischemic Stroke

P Matys, A Mirończuk, A Starosz, K Grubczak… - International Journal of …, 2024 - mdpi.com
… At its core, cerebral ischemia results from an inadequate blood supply to brain tissue. This
deprivation of oxygen and glucose triggers a cascade of detrimental biochemical events. The …

[HTML][HTML] Interleukin-1: an important target for perinatal neuroprotection?

SB Kelly, E Green, RW Hunt… - Neural Regeneration …, 2023 - journals.lww.com
… and subsequent perinatal brain injury. We also highlight the important role of endogenous
interleukin-1 receptor antagonist in mitigating interleukin-1-driven neuroinflammation and …

[HTML][HTML] Neuroinflammation in cerebral ischemia and ischemia/reperfusion injuries: from pathophysiology to therapeutic strategies

A Jurcau, A Simion - International journal of molecular sciences, 2021 - mdpi.com
… Research has shown that neuroinflammatory mechanisms, intimately linked to oxidative …
phase of cerebral ischemia [11], ultimately increasing the magnitude of cerebral damage and …

Interleukin-1 and Interleukin-6 Polymorphisms Might Influence Predisposition to Hemorrhagic Cerebral Vascular Diseases: A Meta-Analysis

J Lin, W Zhang, Z Wang, F Zhao - Neuroimmunomodulation, 2021 - karger.com
… predisposition to various types of cerebral vascular diseases. There were … ischemic cerebral
vascular diseases [13, 14]. So in this meta-analysis, we focused on hemorrhagic cerebral

[HTML][HTML] Hypoxia and interleukin-1-primed mesenchymal stem/stromal cells as novel therapy for stroke

MA Salaudeen, S Allan, E Pinteaux - Human Cell, 2024 - Springer
ischaemic stroke and a defect in the glutamate transporter during stroke has been suggested
as the possible mechanism … in neuronal cell death following cerebral ischemia [29, 30]. …

[HTML][HTML] Interleukins and ischemic stroke

H Zhu, S Hu, Y Li, Y Sun, X Xiong, X Hu… - Frontiers in …, 2022 - frontiersin.org
… nervous system (126, 127), the potential role of IL-15 in astrocytes in cerebral ischemic injury
is not completely clear. However, significant increase in IL-15 expression in astrocytes post …

Preconditioning with interleukin-1 alpha is required for the neuroprotective properties of mesenchymal stem cells after ischemic stroke in mice

R Wong, CJ Smith, SM Allan… - … Cerebral Blood Flow & …, 2023 - journals.sagepub.com
cerebral ischaemia and MSC treatment Transient focal cerebral ischaemia was induced by
middle cerebral … A possible mechanism of MSCs altering CBF may be due to their ability to …

Reduction of mortality, cardiac damage, and cerebral damage by IL-1 inhibition in a murine model of TTP

R Muller, R Cauchois, M Lagarde, S Roffino… - Blood, 2024 - ashpublications.org
… -1β, which bind to the same signaling receptor (interleukin 1 receptor, type 1 [IL-1R1]). …
ischemia, 24 , 25 we aimed to study the implication of IL-1 pathway in cardiac and brain ischemia

[HTML][HTML] Inflammatory regulation of CNS barriers after traumatic brain injury: a tale directed by interleukin-1

CN Bodnar, JB Watson, EK Higgins, N Quan… - Frontiers in …, 2021 - frontiersin.org
… by pro-inflammatory cytokine interleukin-1 (IL-1), might be a mechanism behind changes to
CNS barriers following TBI. This review will highlight the essential and dynamic role of CNS …

[HTML][HTML] … estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self …

N Bai, Q Zhang, W Zhang, B Liu, F Yang… - Journal of …, 2020 - Springer
… following transient global cerebral ischemia (GCI), although the mechanisms remain unclear.
In … in the rat hippocampus after GCI as a potential mechanism to limit neuronal cell death. …