… potential to greatly increase the effectiveness of chemotherapy. Our extensive understanding
of selective COX-2 inhibitor … the widespread administration of selective COX-2 inhibitors as …

… claimed lower potential of serious … treatment of corticosteroids, while the other (ie, COX-2)
is induced by the inflammatory stimuli or cytokines that can be inhibited by the administration of …

… could be a suitable choice as adjuvants in the therapeutic management of … COX-2 inhibitors’
efficacy used alone or as part of combination therapy in melanoma. COX-2 inhibitors tested …

… In addition, such a combination can reduce toxicity and chemoresistance and enhance
radiosensitivity, although COX-2 inhibitors-related cardiotoxicity may potentially affect its use. …

… COX-2 enzyme and production of immunosuppressive prostaglandin E2 (PGE2). This fact
confirmed COX-2 inhibition … the potential benefits of NSAIDs in the prevention and treatment of …

… towards COX-2 inhibition compared to indomethacin. Compounds 3d, 3g and 6a exhibited
significantly increased potency towards COX-2 … Furthermore, the selective COX-2 inhibitor 3g …

… trials with COX-2 inhibitors for cancer prevention or treatment. … and selective COX-2 inhibitors
(COXIBs) on targets beyond … Therefore, there is a potential role for NSAIDs via activation to …

… potential). Celecoxib (1, PDB ID: 3LN1) is superimposed as purple sticks for reference. …
(as 18 F-FDG) uptake from short-term treatment (2 weeks) as an indirect PD surrogate and …

… This review summarizes the roles of COX-2 in the resistance of ICIs and proposes a … COX-2
inhibitors really useful in cancer treatment? COX-2 expression level, metabolites or COX-2-…

… management of cancer-related pain and inflammation. The … of new COX-2 inhibitors due
to their unique role in cancer … radical scavenging potential compared to compound 45 [58]. …