… the predictors. The model was also stable after the introduction of interaction of amiodarone
… to discriminate hepatotoxic action of two amiodarone formulations, but some issues in our …

… Over several decades, a series of case reports have highlighted the incidence of a rare (<0.01%)
and unique type of acute liver injury secondary to the IV infusions of amiodarone.[9] …

… Drug-induced liver injury (DILI) is a frequent cause of liver injury and acute liver failure. We
… Age and prothrombin concentration were the only predictors of unfavorable outcomes of DILI…

… In a review of biopsies performed on DILI patients in the Swedish Adverse Drug Reactions
Advisory Committee (SADRAC) retrospective database, presence of necrosis was predictive …

… Interactions with drugs such as amiodarone, macrolides and fluconazole that inhibit … positive
predictive value for DILI from 85% to 96%, while decreasing the negative predictive value …

… Due to the timing of the patient’s fulminant liver failure, it was discussed and agreed upon …
’s acute liver failure was most likely due to the three doses of oral amiodarone he received. His …

… prediction of IDILI potential of new drug candidates. … given a nontoxic dose of amiodarone
16 hours before a nontoxic … with amiodarone and LPS developed dose-dependent liver injury …

… Antiepileptic drugs are among the leading causes of drug-induced liver injury (DILI). Due
to critical illness, children admitted to intensive care units are more prone to DILI. …

… after years of use (minocycline, nitrofurantoin, statin, amiodarone) [15]. Most DILI cases resolve
… Prediction of liver transplantation or death from liver failure among DILI patients using the …

… liver failure in Western countries.7,8 Aspirin, amiodarone, chemotherapeutic agents, paraquat
(herbicide), carbon tetrachloride, and mushroom poisons may also cause toxic DILI.8–10 …