Pregnenolone: Summary Report
SL Gianturco, LL Pavlech, KD Storm, SJ Yoon… - 2020 - archive.hshsl.umaryland.edu
… to establish the availability of pregnenolone products in the … for pregnenolone; name variations
of pregnenolone were … (OTC) products containing pregnenolone. The availability of OTC …
of pregnenolone were … (OTC) products containing pregnenolone. The availability of OTC …
Effect of pregnenolone vs placebo on self-reported chronic low back pain among US military veterans: A randomized clinical trial
JC Naylor, JD Kilts, LJ Shampine, GJ Parke… - JAMA network …, 2020 - jamanetwork.com
… Individuals randomized to pregnenolone were 2.6 times more likely to report a reduction in
pain intensity ratings of 20% or greater by both pain diary (OR, 2.62; 95% CI, 1.06-6.50; P = .…
pain intensity ratings of 20% or greater by both pain diary (OR, 2.62; 95% CI, 1.06-6.50; P = .…
Function, regulation, and pharmacological effects of pregnenolone in the central nervous system
… reporting altered pregnenolone levels in psychiatric and pain disorders, as well as therapeutic
benefits of pregnenolone … that can most consistently increase pregnenolone levels, the …
benefits of pregnenolone … that can most consistently increase pregnenolone levels, the …
Development and validation of a quantitative proton NMR method for the analysis of pregnenolone
M Schleiff, C Sommers, J Yang, X Shen… - … of Pharmaceutical and …, 2023 - Elsevier
Pregnenolone (PREG) is an endogenous steroid frequently sold as an over-the-counter
dietary supplement touted to promote neurological and immunological health. While the PREG …
dietary supplement touted to promote neurological and immunological health. While the PREG …
The neurosteroid pregnenolone is synthesized by a mitochondrial P450 enzyme other than CYP11A1 in human glial cells
… alternative pathway for glial cell pregnenolone synthesis: (1) … no significant effects on
pregnenolone synthesis, suggesting … deferiprone significantly inhibited pregnenolone production, …
pregnenolone synthesis, suggesting … deferiprone significantly inhibited pregnenolone production, …
New perspectives on the role of the neurosteroid pregnenolone as an endogenous regulator of type‐1 cannabinoid receptor (CB1R) activity and function
PL Raux, G Drutel, JM Revest… - Journal of …, 2022 - Wiley Online Library
… shown to convert pregnenolone to DHEA. In the human brain, postmortem studies report that
… In summary, the tissue-specific expression of steroidogenic enzymes allows the modulation …
… In summary, the tissue-specific expression of steroidogenic enzymes allows the modulation …
Intranasal pregnenolone increases acetylcholine in frontal cortex, hippocampus, and amygdala—Preferentially in the hemisphere ipsilateral to the injected nostril
B Fazari, CI Decheva, V Gonzalez Garcia… - Journal of …, 2020 - Wiley Online Library
… This study determined the effects of intranasal pregnenolone (IN‐PREG) on acetylcholine
(ACh) levels in selected areas of the rat brain, using in vivo microdialysis. Previous studies …
(ACh) levels in selected areas of the rat brain, using in vivo microdialysis. Previous studies …
Differences in Pubertal Curve Progression among Females with Adolescent Idiopathic Scoliosis Using Pregnenolone Therapy: A Retrospective Case-Controlled …
MW Morningstar, B DuRussel - Journal of Clinical Medicine, 2024 - mdpi.com
… This study reports the observations of scoliosis Cobb angle and salivary … given pregnenolone
for low progesterone, as compared to scoliosis patients who declined pregnenolone use or …
for low progesterone, as compared to scoliosis patients who declined pregnenolone use or …
Site of action of brain neurosteroid pregnenolone sulfate at the N-methyl-D-aspartate receptor
BH Krausova, B Kysilov, J Cerny… - Journal of …, 2020 - Soc Neuroscience
… as cholesterol and neurosteroid pregnenolone sulfate (PES). Here we report that PES accesses
… of NMDARs include an endogenous neurosteroid pregnenolone sulfate (PES), but the …
… of NMDARs include an endogenous neurosteroid pregnenolone sulfate (PES), but the …
Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders
S Ramírez, R Haddad-Tovolli, M Radosevic, M Toledo… - Cell metabolism, 2022 - cell.com
… precursor pregnenolone in the hypothalamus. Genetic interference with pregnenolone …
Our data suggest that pregnenolone’s effects on cognitive function were mediated via an …
Our data suggest that pregnenolone’s effects on cognitive function were mediated via an …