Simple Summary Patients with high-grade uterine cancer (UC) have a risk of around 20% of
the cancer spreading to the lymph nodes, while this is only around 10% in patients with low-
grade uterine cancer. CA125 is a marker that can be detected in blood and is associated
with increased tumor spread. Studies on CA125 and its association with tumor spread within
low-grade UC exist but are limited for high-grade UC. The primary aim of this retrospective
study was to assess whether elevated CA125 is predictive for UC spread and survival …

Introduction/Background* Patients with high-grade endometrial carcinoma (EC) have an
increased risk of lymph node metastasis (LNM). Preoperative serum CA125 and imaging
findings have been incorporated in multiple risk stratification models to predict LNM and
advanced disease in EC and are widely used in clinical practice. However, data on their
predictive value in high-grade EC are limited. We therefore aim to determine the predictive
value of CA125 combined with preoperative computed tomography (CT) imaging in high …