[HTML][HTML] THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer

M Omatsu, Y Nakanishi, K Iwane, N Aoyama… - Nature …, 2023 - nature.com
… This study highlights the critical importance of bone marrow (… MTO-inoculated mice, like that
in human CRC, and its stroma-… mice into WT mice and generated GFP-BM chimeric mice for …

[HTML][HTML] … -Specific CD8+ T Cells from the Bone Marrow Resist Exhaustion and Exhibit Increased Persistence in Tumor-Bearing Hosts as Compared to Tumor Infiltrating …

EM Zawidzka, L Biavati, A Thomas, C Zanettini… - bioRxiv, 2023 - ncbi.nlm.nih.gov
… Strategies employing adoptive cell therapy (ACT) have seen the establishment of chimeric
tumor injection, bone marrow was harvested from 5 mice, processed, and prepared for sorting…

[HTML][HTML] Hedgehog-induced PD-L1 on tumor-associated macrophages is critical for suppression of tumor-infiltrating CD8+ T cell function

AJ Petty, R Dai, R Lapalombella, RA Baiocchi… - JCI insight, 2021 - ncbi.nlm.nih.gov
… In this study, we first showed that tumor stroma-derived PD-… PCT (qRT-PCR) using bone
marrow–derived macrophages (BMDMs) … To prepare macrophages, mice were sacrificed and …

[HTML][HTML] Functionally and metabolically divergent melanoma-associated macrophages originate from common bone-marrow precursors

GA Pizzurro, K Bridges, X Jiang, A Vidyarthi… - Cancers, 2023 - mdpi.com
… we previously showed that stromal and tumor cells shape the … processes in tumor-infiltrating
immune cells could be … preparation, to honor Oscar Colegio’s work, legacy and memory. …

[HTML][HTML] Tumor Suppression by Anti-Fibroblast Activation Protein Near-Infrared Photoimmunotherapy Targeting Cancer-Associated Fibroblasts

RA Glabman, CP Olkowski, HA Minor, LL Bassel… - Cancers, 2024 - mdpi.com
… in tumor-infiltrating CD8 T and natural killer cells and … in bone marrow chimeras using
FAP-TK recipients or donors, depletion of FAP + stromal cells and FAP + hematopoietic cells by …

[PDF][PDF] Autonomous IL-36R signaling in neutrophils activates potent antitumor effector functions

S Roy, K Fitzgerald, A Lalani, CW Lai… - Journal of Clinical …, 2023 - Am Soc Clin Investig
… Therefore, we performed bone marrow chimera experiments to tease … Our results highlight
the plasticity of tumor-infiltrating … MC38 cell lysate was prepared by irradiating the cell line at …

Neoantigen presentation and IFNγ signaling on the same tumor-associated macrophage are necessary for CD4 T cell–mediated antitumor activity in mice

A Perez-Diez, X Liu, P Matzinger - Cancer research communications, 2022 - AACR
… was prepared by amplification of 50 ng total RNA using … CD4 T cells, we sorted three
populations of tumor-infiltrating … different bone marrow donor mice to obtain sets of chimera mice

[HTML][HTML] GPR182 limits antitumor immunity via chemokine scavenging in mouse melanoma models

RJ Torphy, Y Sun, R Lin, A Caffrey-Carr… - Nature …, 2022 - nature.com
… due to the paucity of tumor infiltrating lymphocytes. Here we show … , we performed a bone
marrow (BM) chimera experiment … We prepared single-cell suspensions from dLNs from B16-…

Lead in synergism with IFNγ acts on bone marrow-resident macrophages to increase the quiescence of hematopoietic stem cells

Y Zhao, Q Li, T Zhu, J He, P Xue, W Zheng… - Toxicological …, 2021 - academic.oup.com
Functional analyses demonstrated that wild-type mice treated … the BM under a competitive
chimeric microenvironment of lethally … of cells such as osteoblasts, mesenchymal stromal cells, …

[HTML][HTML] Neuronal CaMKK2 promotes immunosuppression and checkpoint blockade resistance in glioblastoma

WH Tomaszewski, J Waibl-Polania… - Nature …, 2022 - nature.com
… of CaMMK2 to tumor-infiltrating immune cell phenotypes. We … KO mice, we again utilized a
bone marrow chimera model. … were prepared using a Chromium Single Cell 3′ Kit using the …